FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312885901> ?p ?o ?g. }

• W4312885901 endingPage "139" @default.
• W4312885901 startingPage "129" @default.
• W4312885901 abstract "Cytochrome P450 (CYP)-mediated metabolisms of four chemicals have been investigated to understand their unresolved phenomena of their metabolisms using human CYP-Template systems developed in our previous studies (Drug Metab Pharmacokinet 2019, 2021, 2022). Simulation experiments of a topoisomerase-targeting agent, amonafide, offered a possible new inhibitory-mechanism as Trigger-residue inactivation on human CYP1A2 Template. N-Acetylamonafide as well as amonafide would inactivate CYP1A2 through the interference of Trigger-residue movement with their dimethylaminoethyl parts. The mechanism was also supported on the inhibition/inactivation of two other drugs, DSP-1053 and binimetinib. Both the drugs, after other CYP-mediated slight structural alterations, were expected to interact with Trigger-residue for the intense inhibition on CYP1A2 Template. Possible formation of reactive intermediates of amonafide and 3-methylindole was also examined on CYP1A2 Template. Placements of amonafide suggested the scare N-oxidation of the arylamine part due to the Trigger-residue interaction. Placements of 3-methylindole suggested the formation of a reactive intermediate, 3-methyleneindolenine, rather selectively on rodent CYP1A2 than on human CYP1A2, in consistent with the experimental data. These results suggest that CYP Template systems developed are effective tools to warn an appearance of unstable reactive intermediates. Our CYP-Template systems would support confident judgements in safety assessments through offering the mechanistic understandings of the metabolism." @default.
• W4312885901 created "2023-01-05" @default.
• W4312885901 creator A5013368069 @default.
• W4312885901 creator A5037843407 @default.
• W4312885901 creator A5069722397 @default.
• W4312885901 date "2022-01-01" @default.
• W4312885901 modified "2023-09-25" @default.
• W4312885901 title "Application of CYP1A2-Template System to Understand Metabolic Processes in the Safety Assessment" @default.
• W4312885901 cites W1786438296 @default.
• W4312885901 cites W1894712186 @default.
• W4312885901 cites W1900740515 @default.
• W4312885901 cites W1963882044 @default.
• W4312885901 cites W1964390319 @default.
• W4312885901 cites W2016552593 @default.
• W4312885901 cites W2025949533 @default.
• W4312885901 cites W2027918953 @default.
• W4312885901 cites W2036504837 @default.
• W4312885901 cites W2040776357 @default.
• W4312885901 cites W2056649327 @default.
• W4312885901 cites W2058864601 @default.
• W4312885901 cites W2067559257 @default.
• W4312885901 cites W2068184990 @default.
• W4312885901 cites W2086401995 @default.
• W4312885901 cites W2112497968 @default.
• W4312885901 cites W2114627545 @default.
• W4312885901 cites W2119454367 @default.
• W4312885901 cites W2119955031 @default.
• W4312885901 cites W2125353417 @default.
• W4312885901 cites W2142926482 @default.
• W4312885901 cites W2143660311 @default.
• W4312885901 cites W2152795244 @default.
• W4312885901 cites W2515161387 @default.
• W4312885901 cites W2618992229 @default.
• W4312885901 cites W2807965602 @default.
• W4312885901 cites W2896577385 @default.
• W4312885901 cites W2913848986 @default.
• W4312885901 cites W2925705027 @default.
• W4312885901 cites W2985011796 @default.
• W4312885901 cites W3002631769 @default.
• W4312885901 cites W3040849290 @default.
• W4312885901 cites W3043426173 @default.
• W4312885901 cites W3087148630 @default.
• W4312885901 cites W3126242354 @default.
• W4312885901 cites W3138574842 @default.
• W4312885901 cites W3195400543 @default.
• W4312885901 cites W4210399539 @default.
• W4312885901 cites W4296917987 @default.
• W4312885901 cites W4308743204 @default.
• W4312885901 cites W3037868743 @default.
• W4312885901 doi "https://doi.org/10.14252/foodsafetyfscj.d-22-00008" @default.
• W4312885901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36619007" @default.
• W4312885901 hasPublicationYear "2022" @default.
• W4312885901 type Work @default.
• W4312885901 citedByCount "3" @default.
• W4312885901 countsByYear W43128859012023 @default.
• W4312885901 crossrefType "journal-article" @default.
• W4312885901 hasAuthorship W4312885901A5013368069 @default.
• W4312885901 hasAuthorship W4312885901A5037843407 @default.
• W4312885901 hasAuthorship W4312885901A5069722397 @default.
• W4312885901 hasBestOaLocation W43128859011 @default.
• W4312885901 hasConcept C12554922 @default.
• W4312885901 hasConcept C161790260 @default.
• W4312885901 hasConcept C181199279 @default.
• W4312885901 hasConcept C185592680 @default.
• W4312885901 hasConcept C192937433 @default.
• W4312885901 hasConcept C2781338088 @default.
• W4312885901 hasConcept C526171541 @default.
• W4312885901 hasConcept C55493867 @default.
• W4312885901 hasConcept C70721500 @default.
• W4312885901 hasConcept C86745063 @default.
• W4312885901 hasConcept C86803240 @default.
• W4312885901 hasConcept C98274493 @default.
• W4312885901 hasConceptScore W4312885901C12554922 @default.
• W4312885901 hasConceptScore W4312885901C161790260 @default.
• W4312885901 hasConceptScore W4312885901C181199279 @default.
• W4312885901 hasConceptScore W4312885901C185592680 @default.
• W4312885901 hasConceptScore W4312885901C192937433 @default.
• W4312885901 hasConceptScore W4312885901C2781338088 @default.
• W4312885901 hasConceptScore W4312885901C526171541 @default.
• W4312885901 hasConceptScore W4312885901C55493867 @default.
• W4312885901 hasConceptScore W4312885901C70721500 @default.
• W4312885901 hasConceptScore W4312885901C86745063 @default.
• W4312885901 hasConceptScore W4312885901C86803240 @default.
• W4312885901 hasConceptScore W4312885901C98274493 @default.
• W4312885901 hasIssue "4" @default.
• W4312885901 hasLocation W43128859011 @default.
• W4312885901 hasLocation W43128859012 @default.
• W4312885901 hasLocation W43128859013 @default.
• W4312885901 hasOpenAccess W4312885901 @default.
• W4312885901 hasPrimaryLocation W43128859011 @default.
• W4312885901 hasRelatedWork W2055114422 @default.
• W4312885901 hasRelatedWork W2091987664 @default.
• W4312885901 hasRelatedWork W2398743016 @default.
• W4312885901 hasRelatedWork W2398870805 @default.
• W4312885901 hasRelatedWork W2535731211 @default.
• W4312885901 hasRelatedWork W2727479841 @default.
• W4312885901 hasRelatedWork W2894875257 @default.
• W4312885901 hasRelatedWork W3152564362 @default.

• next