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- W4312914832 endingPage "27" @default.
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- W4312914832 abstract "Drug-metabolizing enzymes (DMEs) perform a crucial role in the metabolism of xenobiotics, especially the drugs. These DMEs also lead to the conversion of prodrugs into their active form, which mediates more pharmacological activity. DMEs are categorized based on their method of metabolizing the drugs such as oxidative, reductive, and/or conjugative enzymes. These DMEs have their bio-activation pathways as well as the specific mechanism of action to perform their function. The biotransformation pathway is classified into three phases and produces a metabolite that is pharmacologically inactive and excreted from the body in nontoxic and/or relatively less toxic form. Among the DMEs, cytochrome P450 enzymes (CYP450s) are the predominant players. Certain drugs or chemical substances exhibit inhibitory or stimulatory effects on DMEs, thus altering the normal metabolism of other drugs. Thus, the knowledge of DMEs is quite essential for achieving the maximum therapeutic effects and safeguarding the undesirable attributes like subtherapeutic or toxic effects." @default.
- W4312914832 created "2023-01-05" @default.
- W4312914832 creator A5032522966 @default.
- W4312914832 creator A5039116948 @default.
- W4312914832 creator A5066820510 @default.
- W4312914832 creator A5077022191 @default.
- W4312914832 creator A5088890139 @default.
- W4312914832 date "2022-01-01" @default.
- W4312914832 modified "2023-09-27" @default.
- W4312914832 title "Biochemical activation and functions of drug-metabolizing enzymes" @default.
- W4312914832 cites W1701383845 @default.
- W4312914832 cites W1850156578 @default.
- W4312914832 cites W1972899609 @default.
- W4312914832 cites W1978182027 @default.
- W4312914832 cites W1982796326 @default.
- W4312914832 cites W1984116651 @default.
- W4312914832 cites W1985152937 @default.
- W4312914832 cites W1985973559 @default.
- W4312914832 cites W1994025158 @default.
- W4312914832 cites W1995104163 @default.
- W4312914832 cites W1996603307 @default.
- W4312914832 cites W1997115553 @default.
- W4312914832 cites W2003562401 @default.
- W4312914832 cites W2004078197 @default.
- W4312914832 cites W2011013568 @default.
- W4312914832 cites W2014813930 @default.
- W4312914832 cites W2015484641 @default.
- W4312914832 cites W2016623506 @default.
- W4312914832 cites W2021836517 @default.
- W4312914832 cites W2028021548 @default.
- W4312914832 cites W2028469253 @default.
- W4312914832 cites W2029338784 @default.
- W4312914832 cites W2029988617 @default.
- W4312914832 cites W2031053490 @default.
- W4312914832 cites W2034929515 @default.
- W4312914832 cites W2038700662 @default.
- W4312914832 cites W2039826443 @default.
- W4312914832 cites W2041666513 @default.
- W4312914832 cites W2041770136 @default.
- W4312914832 cites W2047259762 @default.
- W4312914832 cites W2047377849 @default.
- W4312914832 cites W2058342217 @default.
- W4312914832 cites W2059793781 @default.
- W4312914832 cites W2062063512 @default.
- W4312914832 cites W2064245899 @default.
- W4312914832 cites W2068608069 @default.
- W4312914832 cites W2072149941 @default.
- W4312914832 cites W2075550795 @default.
- W4312914832 cites W2078086567 @default.
- W4312914832 cites W2086254726 @default.
- W4312914832 cites W2094826665 @default.
- W4312914832 cites W2094879937 @default.
- W4312914832 cites W2100901456 @default.
- W4312914832 cites W2106219747 @default.
- W4312914832 cites W2122815214 @default.
- W4312914832 cites W2124606330 @default.
- W4312914832 cites W2129077714 @default.
- W4312914832 cites W2131942336 @default.
- W4312914832 cites W2132899427 @default.
- W4312914832 cites W2135910194 @default.
- W4312914832 cites W2138028060 @default.
- W4312914832 cites W2138393164 @default.
- W4312914832 cites W2144084200 @default.
- W4312914832 cites W2149874329 @default.
- W4312914832 cites W2157400187 @default.
- W4312914832 cites W2167832449 @default.
- W4312914832 cites W2289764719 @default.
- W4312914832 cites W2295882128 @default.
- W4312914832 cites W2322012164 @default.
- W4312914832 cites W2332042251 @default.
- W4312914832 cites W2337077673 @default.
- W4312914832 cites W2410942593 @default.
- W4312914832 cites W2538201653 @default.
- W4312914832 cites W2581481137 @default.
- W4312914832 cites W2590595176 @default.
- W4312914832 cites W2610683753 @default.
- W4312914832 cites W2614040182 @default.
- W4312914832 cites W2729775538 @default.
- W4312914832 cites W2734440527 @default.
- W4312914832 cites W2741590375 @default.
- W4312914832 cites W2742803394 @default.
- W4312914832 cites W2744560242 @default.
- W4312914832 cites W2765173544 @default.
- W4312914832 cites W2773380132 @default.
- W4312914832 cites W2897568450 @default.
- W4312914832 cites W2901424664 @default.
- W4312914832 cites W2914012452 @default.
- W4312914832 cites W2946885747 @default.
- W4312914832 cites W2963028651 @default.
- W4312914832 cites W2968147454 @default.
- W4312914832 cites W2971828090 @default.
- W4312914832 cites W2982484248 @default.
- W4312914832 cites W2997370174 @default.
- W4312914832 cites W3033064550 @default.
- W4312914832 cites W4231680606 @default.
- W4312914832 cites W4238420766 @default.
- W4312914832 cites W1984928719 @default.
- W4312914832 doi "https://doi.org/10.1016/b978-0-323-95120-3.00021-x" @default.