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- W4312933257 abstract "Chronic obstructive pulmonary disease COPD is a progressive degenerative lung disease. The third or fourth leading cause of death worldwide for which currently there is no effective cure or treatment. Small Mobile Stem (SMS) cells have demonstrated the ability to secrete important matrisomal proteins, bind and stimulate key regenerative cells of the lung, and to stimulate the formation of blood vessel. The multitargeted effect of SMS cells on the regeneration of lung alveoli has been examined <i>in vivo</i> using an elastase enzyme induced rat emphysema model. The instillation of SMS cells through the trachea resulted in significant regeneration of alveoli in the rat model. The histopathological parameter related to alveoli destruction, the Mean Linear Intercept (MLI), was measured in paraffin embedded tissue cross-sections of inflated rat lungs. Using multiple regimens, including one with a mere one week distance from SMS cell administration, a shift towards a significantly lower MLI value equaling a regenerative effect of 66 to 78 % was achieved. Functional testing of the rat emphysema animal model corroborated the obtained histological MLI measurements. SMS cells demonstrate the <i>in vivo</i> potential for significant lung tissue regeneration; coupled with their intrinsic resilience, this finding would pave the way to clinical investigation of COPD patients suffering from lung emphysema." @default.
- W4312933257 created "2023-01-05" @default.
- W4312933257 creator A5062700044 @default.
- W4312933257 date "2022-09-04" @default.
- W4312933257 modified "2023-09-28" @default.
- W4312933257 title "Small mobile stem cells multitargeted approach to alveoli in vivo regeneration" @default.
- W4312933257 doi "https://doi.org/10.1183/13993003.congress-2022.3377" @default.
- W4312933257 hasPublicationYear "2022" @default.
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