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- W4312944348 abstract "<h3>Introduction/Background</h3> Anaemia is common in patients with cervical cancer. Existing guidelines emphasise the importance of maintaining haemoglobin levels above 120 g/L in cervical cancer patients undergoing chemoradiation. The aim of the study is to evaluate the impact of anaemia on the clinical outcomes in patients with cervical cancer referred for chemoradiation. <h3>Methodology</h3> 135 patients (median age was 48 years) with cervical cancer (squamous= 79.3%, Adenocarcinoma= 12.6%, Adenosquamous= 8.1%) referred for radical chemoradiartion between January 2013 and December 2017 were reviewed retrospectively. The FIGO stages for the group were: Ib2 = 11%; II = 42%; III = 39%; IVa =8%. Patients underwent chemoradiation with external beam radiotherapy with concurrent weekly cisplatin for five cycles followed by high-dose-rate brachytherapy. Factors included in the analysis were age, histology, FIGO stage, nodal status, pre-treatment haemoglobin, pre-brachytherapy haemoglobin and post treatment haemoglobin. <h3>Results</h3> After a median follow-up of 42 months, the 3 year local failure rate for the whole group, pre-treatment Hb < 120 g/L and pre-brachytherapy Hb < 120 g/L was 9%, 15% and 22% respectively. The 3 year overall survival rate was 72%, 65% and 49% respectively. 52 patients (38.5%) had anaemia at presentation (Hb < 120 g/L). There was significant association between anaemia and younger age, more advanced stage and lymph node involvement. Anaemia was corrected by blood transfusion and/or ferric carboxymaltose. The pre-brachytherapy Hb level had the strongest impact on both local failure and survival. The post-treatment Hb level did not have an impact on the outcomes. <h3>Conclusion</h3> Anaemia in patients with cervical cancer undergoing chemoradiation was a strong prognostic factor for local control and survival. The pre-brachytherapy Hb level had the strongest impact indicating the benefit from correcting the anaemia before treatment and maintaining the Hb level above 120 g/L during the treatment." @default.
- W4312944348 created "2023-01-05" @default.
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- W4312944348 date "2022-10-01" @default.
- W4312944348 modified "2023-10-18" @default.
- W4312944348 title "2022-RA-1042-ESGO The prognostic impact of anaemia in cervical cancer patients treated with chemoradiation" @default.
- W4312944348 doi "https://doi.org/10.1136/ijgc-2022-esgo.84" @default.
- W4312944348 hasPublicationYear "2022" @default.
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