Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312948252> ?p ?o ?g. }
- W4312948252 abstract "Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains eNOS in the inactivated state leading to reduced nitric oxide (NO) production. Ischemic preconditioning disrupts the caveolin-eNOS complex leading to activation of the eNOS and thus results in cardioprotection. During ischemic preconditioning, NO produces cardioprotection by the opening of the KATP channel, and the caveolin forms a suitable signalling platform facilitating the interaction of NO with the KATP channel. Estrogen deficiency has been reported to upregulate caveolin-1 expression. The article aims to review the various mechanisms that placed the women at the risk of coronary artery diseases after postmenopausal estrogen deficiency and their role in the cardioprotective effect of ischemic preconditioning." @default.
- W4312948252 created "2023-01-05" @default.
- W4312948252 creator A5002121999 @default.
- W4312948252 creator A5010369880 @default.
- W4312948252 creator A5065342351 @default.
- W4312948252 creator A5066946532 @default.
- W4312948252 creator A5090328367 @default.
- W4312948252 date "2022-01-01" @default.
- W4312948252 modified "2023-10-14" @default.
- W4312948252 title "Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women" @default.
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