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- W4312972930 abstract "Background: T2 GBC is subdivided into T2a and T2b by AJCC 8th edition staging system. However, there is a lack of evidence on the prognostic significance of tumor location. The aim of the present study was to examine the existing evidence to determine the prognostic significance of tumor location of T2 gallbladder cancer(GBC) and to evaluate the optimal surgical extent according to tumor location. Methods: We searched for relevant literature published in the electronic databases PubMed, Medline, Web of Science, Cochrane Library, and Embase before September, 2020using search terms related to gallbladder, cancer, and stage. Data were weighted and pooled using random-effects modeling. Results: Seven studies were deemed eligible for inclusion representing a cohort of 1,789 case of resected T2 GBC. The overall survival for T2b tumor was significantly worse than that for T2a tumor (HR, 2.141; 95% confidence interval (CI), 1.140 to 4.023; I2= 71.4%; Pchi2=0.007). The rate of lymph node metastasis was lower in T2a group (26.6%) than in T2b group (36.6%) (OR, 2.164; 95% CI, 1.309 to 3.575). There was no evidence of a survival difference between the patients who underwent extended cholecystectomy and simple cholecystectomy in T2a GBC (OR, 0.802; 95% CI, 0.618 to 1.042) and T2b GBC (OR, 0.820; 95% CI, 0.620 to 1.083). Conclusions: Hepatic side tumor was significant poor prognostic factor in T2 GBC. Extended cholecystectomy and simple cholecystectomy showed comparable survival outcomes in T2 GBC and additional large-scale prospective studies are warranted to establish evidence-based treatment guidelines for T2 GBC." @default.
- W4312972930 created "2023-01-05" @default.
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- W4312972930 date "2022-01-01" @default.
- W4312972930 modified "2023-09-30" @default.
- W4312972930 title "Prognostic Significance of Tumor Location in T2 Gallbladder Cancer: A Systematic Review and Meta-analysis" @default.
- W4312972930 doi "https://doi.org/10.1016/j.hpb.2022.05.1044" @default.
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