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- W4312979240 abstract "The mechanical properties of cells provide key insights into the type, differentiation and/or pathology of a cell. The mechanical analysis of a cell population, such as a blood sample, enables meaningful biological and medical interpretation for the diagnosis and monitoring of diseases. There are number of diseases, which alter the mechanical properties of human red blood cells (RBCs). Here, an acoustic method to probe both the viscous and elastic mechanics of single RBCs by SAW in a microfluidic device is presented. The device operates by exciting a surface acoustic wave in a microfluidic channel creating a stationary acoustic wave field of nodes and antinodes. RBCs are attracted to the nodes and are deformed. Using a stepwise increasing and periodically oscillating acoustic field, the static and dynamic deformation of individual red blood cells one by one was studied and the deformation by the Taylor deformation index D and relaxation times were quantified. The precision of the measurement allows to distinguish between individual cells in the suspension and provides a quantitative viscoelastic fingerprint of the blood sample with a resolution of a single cell. The method overcomes limitations of other techniques that provide averaged values and has the potential for high-throughput screening." @default.
- W4312979240 created "2023-01-05" @default.
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- W4312979240 date "2022-10-01" @default.
- W4312979240 modified "2023-09-30" @default.
- W4312979240 title "Acoustic erythrocytometer for mechanical cell probing" @default.
- W4312979240 doi "https://doi.org/10.1121/10.0015456" @default.
- W4312979240 hasPublicationYear "2022" @default.
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