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- W4313000980 abstract "(+)-1,1’-Bislunatin (Bsl) is a bisanthraquinone isolated from the endophytic fungus Diaporthe sp. GNBP-10 derived from the gambier plant (Uncaria gambier Roxb.). This study aims to evaluate the hypoglycemic effect of Bsl in experimental diabetic male mice. DDY Male mice were induced with streptozotocin (STZ) at a dose of 40 mg/kg BW intraperitoneal for 5 consecutive days to obtain experimental diabetic mice. The treatments in this study included: (1) normal control group (without STZ induction), (2) negative control group (STZ induction), (3) positive control group (STZ induction and metformin administration), (4) Bsl treatment 20 mg/kg BW, (5) Bsl treatment 100 mg/kg BW, (6) Bsl treatment 500 mg/kg BW. The results showed that Bsl treatment with various doses could reduce blood glucose levels as well as a positive control (the group with metformin treatment) (p <0.05). There was no significant difference between the normal control, all Bsl test groups, and positive control. This fact indicates that Bsl could return blood glucose levels to a normal level for STZ-induced diabetic mice and the positive control. The results of Bsl treatment in STZ-induced diabetic mice can reduce blood glucose levels, and this compound is expected to be a safer candidate for type 2 diabetes drugs. Further research related to in-vivo tests using other experimental animals is still needed to prove the efficacy of the Bsl compound." @default.
- W4313000980 created "2023-01-05" @default.
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- W4313000980 date "2022-01-01" @default.
- W4313000980 modified "2023-09-25" @default.
- W4313000980 title "Evaluation of hypoglycemic effect of (+)-1,1’-Bislunatin in streptozotocin-induced DDY male mice (Mus musculus)" @default.
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- W4313000980 doi "https://doi.org/10.1063/5.0110278" @default.
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