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- W4313007893 abstract "<b>Aims and objectives:</b> We evaluated 59 different potential protein based biomarkers in a population of subjects with fibrosing interstitial diseases in order to identify new diagnostic and/or prognostic biomarkers. <b>Methods:</b> The present exploratory study included 66 patients, 24 IPF patients and 42 patients with other ILDs (including 6 iNSIP, 6 CHP and 16 CTD-ILD, 6 Unclassifiable IIPS and 8 other ILDs). Serum samples were collected during patients9 diagnostic workout and patients were followed for a period of 52 weeks. The analysis of 59 serum proteins was carried out using magnetic bead‐based multiplex immunoas‐says. The results were correlated with patients diagnosis and disease progression defined as a decline in FVC >10%, DlCO >15% or 6MWTD >30% during the period of observation. <b>Results:</b> Data analysis on levels of the 59 proteins led to the identification of 6 molecules that were differently expressed in patients that progressed during follow-up period: Periostin, Eotaxin, HGF, SCGF-b, COMP (thrombospondin- 5), IL-4. Importantly those results were independent from patients diagnosis suggesting their role as specific prognostic biomarkers. <b>Conclusions:</b> The results of this study propose new potential prognostic biomarker for the early identification of Progressive Pulmonary Fibrosis" @default.
- W4313007893 created "2023-01-05" @default.
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- W4313007893 date "2022-09-04" @default.
- W4313007893 modified "2023-09-28" @default.
- W4313007893 title "Proteomic profiling for the development of new serum based diagnostic and prognostic biomarkers in Progressive Pulmonary Fibrosis." @default.
- W4313007893 doi "https://doi.org/10.1183/13993003.congress-2022.3661" @default.
- W4313007893 hasPublicationYear "2022" @default.
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