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- W4313010955 abstract "NDV is used as a model for oncolytic against certain cell lines. Current study aims to estimate the oncolytic effect of NDV strain LaSota against Iraqi human breast cancer cell line. Methyl thiazoly ltetrazolium assay (MTT) used different Multiplicity of infection (MOI) on (AMJ13) incubated for 72 hours post-infection. The infective dose (IC50) values and anti-tumor activity of LaSota strain against AMJ13 cell line were determined. Human breast cancer cells AMJ13 were analyzed using acridine orange. In infected chicken embryos, the NDV strain LaSota was induced to die. Our data of oncolytic study indicate that anti-tumor behavior of LaSota strain triggers a dose-dependent manner. 20MOI of the virus was found to have a strong inhibition against Amj13 growth after 72hrs using the oncolytic test; the inhibition rate was 50.6 percent. Our data showed that NDV had the ability to induce the caspase-dependent cascade of apoptosis. The semi-quantitative PCR technique revealed the increase of gene expression of caspase 9. Simultaneously, the treatment with NDV has no effect on caspase 3 and 8. In conclusions, NDV LaSota strain had oncolytic effects by destroying cancer cells in AMJ13 cancer cells, and triggering the death cells pathway may result from caspase-independent apoptosis. However, the mechanisms of the in vivo anti- cancer activity need to be better understood." @default.
- W4313010955 created "2023-01-05" @default.
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- W4313010955 date "2022-01-01" @default.
- W4313010955 modified "2023-10-17" @default.
- W4313010955 title "The anti-cancer effect of LaSota strain of Newcastle Disease Virus (NDV) against Iraqi breast cancer cell line AMJ13" @default.
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- W4313010955 doi "https://doi.org/10.1063/5.0094322" @default.
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