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- W4313014549 abstract "Introduction: Neuroendocrine neoplasm is an uncommon tumor that can develop in different organ including pancreas. Even its rare tumor, surgical treatment is the best treatment in resectable case. This study aimed to evaluate surgical outcomes and prognosis after surgery. Methods: Retrospectively review of patients underwent pancreatic surgery for neuroendocrine neoplasms during 2007–2019. Their clinical characteristic, pathological reports and surgical outcomes were analyzed. Results: Fifty-three patients of pancreatic neuroendocrine neoplasms were included. Thirty-seven patients (69.8%) were female with an average age of 53.2±14.1 years. The operations consist of pancreaticoduodenectomy (28.3%), distal pancreatectomy (52.8%), enucleation (13.2%), and total pancreatectomy (5.7%). There were 49 patients (92.5%) of neuroendocrine tumor (NET) and 4 patients (7.5%) of neuroendocrine carcinoma (NEC) according to the current WHO classification 2019. Two patients (3.8%) were firstly diagnosed with liver metastasis and 13 patients (24.5%) had recurrent disease with a median time of 657 days. Forty-one patients were still alive. The median follow-up time was 3.5 years. The overall survival rates were 94.3%, 92.0%, and 75.1% at 1, 3, and 5 years, respectively. The factors affect 3-year survival were low pre-operative albumin level (p=0.036), pathological report of NEC (p=0.047), poorly differentiated tumor (p=0.047), grade G3 of tumor (p=0.017), high Ki-67 index (p=0.017), positive lymph node (p=0.044), and liver metastasis (p=0.048). Conclusions: Patients with resectable pancreatic neuroendocrine neoplasms had long term survival. The good prognostic factors were high pre-operative albumin level, pathological report of NET, well differentiated, low grading tumor, low Ki-67 index, no lymph node and liver metastasis." @default.
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- W4313014549 date "2022-01-01" @default.
- W4313014549 modified "2023-10-15" @default.
- W4313014549 title "Surgical Outcomes of Pancreatic Neuroendocrine Neoplasms at Siriraj Hospital" @default.
- W4313014549 doi "https://doi.org/10.1016/j.hpb.2022.05.729" @default.
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