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- W4313016568 abstract "Abstract Apoptosis of neutrophils is a key mechanism to control the intensity of the acute inflammatory response. Previously, the cytokine tumor necrosis factor α (TNF-α) was reported by some to have pro-apoptotic and by others to have anti-apoptotic effects on neutrophils. The aim of this study was to explain these contradictory results. We found that TNF-α at low concentrations strongly decreased apoptosis of neutrophils. However, at higher concentrations, TNF-α lost its protective effects, and also reversed the protective effects of interferon-γ (IFN-γ) and granulocyte-macrophage colony-stimulating factor (GM-CSF). This pro-apoptotic effect of TNF-α was blocked by anti-CD11b and was absent in neutrophils from patients with chronic granulomatous disease, which cannot produce toxic oxygen metabolites. Under these circumstances, we found that TNF-α retained its anti-apoptotic effects even at high concentrations. In conclusion, the protective effects against apoptosis of IFN-γ, GM-CSF, and TNF-α itself are overruled when the concentration of TNF-α is high enough to produce a respiratory burst. These dual, concentration-dependent effects of TNF-α provide an explanation for previous controversial reports and support a dominant role for TNF-α in neutrophil apoptosis." @default.
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- W4313016568 date "2001-03-01" @default.
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- W4313016568 title "Divergent effects of tumor necrosis factor α on apoptosis of human neutrophils" @default.
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- W4313016568 doi "https://doi.org/10.1189/jlb.69.3.467" @default.
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