Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313016682> ?p ?o ?g. }
- W4313016682 endingPage "25" @default.
- W4313016682 startingPage "1" @default.
- W4313016682 abstract "In the initial simplistic understanding, childhood retinal cancer retinoblastoma is due to the defect in the retinoblastoma gene. However, the deep insights reveal the complexity of the disease from unilateral single gene mutation to the bilateral two-hit hypothesis proposing two mutations in two alleles of the same gene and more recent studies revealing the role of multigene dysfunction in such cancers without any abnormality in the retinoblastoma gene. Again, retinoblastoma majorly occurs among humans while replicating the same disease among animals with the mutations in Rb gene shows more complexity to the evolution of the disease as the Rb gene mutations alone do not result in the diseased retina in the organism. Thus, it has become vital to develop various alternatives to study disease initiation, development, and treatment. Here we summarize the current understandings of the disease, in vitro, ex vivo, and animal models, and the standard treatment procedures as well as the development of novel therapeutics for such a complex disease." @default.
- W4313016682 created "2023-01-05" @default.
- W4313016682 creator A5021746642 @default.
- W4313016682 creator A5049576242 @default.
- W4313016682 creator A5049713101 @default.
- W4313016682 creator A5052514601 @default.
- W4313016682 creator A5064266185 @default.
- W4313016682 creator A5070284845 @default.
- W4313016682 creator A5072687611 @default.
- W4313016682 date "2022-01-01" @default.
- W4313016682 modified "2023-09-30" @default.
- W4313016682 title "Tumor Models of Retinoblastoma: In Vivo, Ex Vivo, and In Vitro Models" @default.
- W4313016682 cites W168561149 @default.
- W4313016682 cites W1827831640 @default.
- W4313016682 cites W1857598851 @default.
- W4313016682 cites W1972912013 @default.
- W4313016682 cites W1973757037 @default.
- W4313016682 cites W1977505235 @default.
- W4313016682 cites W1985712533 @default.
- W4313016682 cites W1986480161 @default.
- W4313016682 cites W1990547724 @default.
- W4313016682 cites W2012421299 @default.
- W4313016682 cites W2019567173 @default.
- W4313016682 cites W2022579060 @default.
- W4313016682 cites W2025439675 @default.
- W4313016682 cites W2027973996 @default.
- W4313016682 cites W2034440981 @default.
- W4313016682 cites W2041666810 @default.
- W4313016682 cites W2044380274 @default.
- W4313016682 cites W2046746208 @default.
- W4313016682 cites W2049929214 @default.
- W4313016682 cites W2051404433 @default.
- W4313016682 cites W2052161022 @default.
- W4313016682 cites W2061004473 @default.
- W4313016682 cites W2061637512 @default.
- W4313016682 cites W2063640158 @default.
- W4313016682 cites W2064110274 @default.
- W4313016682 cites W2065256910 @default.
- W4313016682 cites W2065774119 @default.
- W4313016682 cites W2068810998 @default.
- W4313016682 cites W2071531151 @default.
- W4313016682 cites W2074511633 @default.
- W4313016682 cites W2076392163 @default.
- W4313016682 cites W2080852522 @default.
- W4313016682 cites W2082826505 @default.
- W4313016682 cites W2084263257 @default.
- W4313016682 cites W2105291626 @default.
- W4313016682 cites W2121296688 @default.
- W4313016682 cites W2121932526 @default.
- W4313016682 cites W2123615277 @default.
- W4313016682 cites W2127946085 @default.
- W4313016682 cites W2131488073 @default.
- W4313016682 cites W2141596803 @default.
- W4313016682 cites W2142174429 @default.
- W4313016682 cites W2145798539 @default.
- W4313016682 cites W2148209107 @default.
- W4313016682 cites W2163623189 @default.
- W4313016682 cites W2166510225 @default.
- W4313016682 cites W2279619364 @default.
- W4313016682 cites W2315192299 @default.
- W4313016682 cites W2334205130 @default.
- W4313016682 cites W2396141880 @default.
- W4313016682 cites W2404113298 @default.
- W4313016682 cites W2588290850 @default.
- W4313016682 cites W2724385814 @default.
- W4313016682 cites W2746687954 @default.
- W4313016682 cites W2756013212 @default.
- W4313016682 cites W2761038890 @default.
- W4313016682 cites W2765469223 @default.
- W4313016682 cites W2785220350 @default.
- W4313016682 cites W2791064759 @default.
- W4313016682 cites W2808342972 @default.
- W4313016682 cites W2896680207 @default.
- W4313016682 cites W2918611150 @default.
- W4313016682 cites W2961998941 @default.
- W4313016682 cites W2998852845 @default.
- W4313016682 cites W3041722505 @default.
- W4313016682 cites W3046042068 @default.
- W4313016682 cites W3101291291 @default.
- W4313016682 cites W3118541347 @default.
- W4313016682 cites W3143900684 @default.
- W4313016682 doi "https://doi.org/10.1007/978-981-19-1282-5_30-1" @default.
- W4313016682 hasPublicationYear "2022" @default.
- W4313016682 type Work @default.
- W4313016682 citedByCount "0" @default.
- W4313016682 crossrefType "book-chapter" @default.
- W4313016682 hasAuthorship W4313016682A5021746642 @default.
- W4313016682 hasAuthorship W4313016682A5049576242 @default.
- W4313016682 hasAuthorship W4313016682A5049713101 @default.
- W4313016682 hasAuthorship W4313016682A5052514601 @default.
- W4313016682 hasAuthorship W4313016682A5064266185 @default.
- W4313016682 hasAuthorship W4313016682A5070284845 @default.
- W4313016682 hasAuthorship W4313016682A5072687611 @default.
- W4313016682 hasConcept C104317684 @default.
- W4313016682 hasConcept C121608353 @default.
- W4313016682 hasConcept C142724271 @default.
- W4313016682 hasConcept C19843653 @default.
- W4313016682 hasConcept C207001950 @default.