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- W4313017715 abstract "<b>Introduction:</b> Lung inflammation in stable COPD is similar to that of bacterial infection. It is unclear whether the bacterial microbiome has a role in COPD pathogenesis. <b>Methods:</b> Bronchoalveolar lavage was collected from the right middle lobe of 88 COPD patients and 88 healthy controls via bronchoscopy. Whole genome sequencing was performed on the Illumina NovaSeq platform. Identification of OTUs was made by the GAIA 2.0-software. Statistical analyses were performed in R (Phyloseq-package). <b>Results:</b> Alpha diversity (Shannon and Simpson) was not significantly different between COPD patients and controls, whereas Beta diversity evaluated by Bray-Curtis dissimilarity was significantly different between the groups using ANOVA, p=0.003 (figure 1). The top five over-represented species found in COPD patients were Tropheryma whipplei, Alloscardovia omnicolens, Filifactor alocis, Streptococcus pyogenes and Bulleidia extructa. <b>Conclusion:</b> COPD patients may have a different lung microbiome than healthy controls. The role of the microbiome in COPD pathophysiology should be further investigated." @default.
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- W4313017715 date "2022-09-04" @default.
- W4313017715 modified "2023-09-27" @default.
- W4313017715 title "The role of the microbiome in COPD" @default.
- W4313017715 doi "https://doi.org/10.1183/13993003.congress-2022.3745" @default.
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