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- W4313019675 abstract "<b>Introduction:</b> All biological treatments improve lung function and symptoms in clinical trials, however the fastness of action has not been properly studied. <b>Aims:</b> To compare the early improvement of asthma control test (ACT) and forced expiratory volume in 1s (FEV<sub>1</sub>) after three different biological treatments in severe asthma patients. <b>Methods:</b> Retrospective observational study. Patients treated between 2018-2021 with omalizumab, benralizumab and mepolizumab at least for 3 months, were included. Demographic variables, administered drug and treatment effectiveness (ACT:baseline-1-3 months and FEV<sub>1</sub>:baseline-3 months) were collected. <b>Results:</b> Seventy patients (41(58.6%) females) with 53.0±15.2 years. Thirty-six (51.4%) received omalizumab, 19(27.2%) benralizumab and 15 (21.4%) mepolizumab. ACT improvement was significative (p<0.05) at 3 months respect baseline in all groups. Patients with omalizumab (p=0.01) and benralizumab (p<0.0001) showed a significative clinical improvement at 1 month. FEV<sub>1</sub> improvement was significative in omalizumab (p=0.02) and benralizumab (p=0.003) groups after 3 months treatment. <b>Conclusions:</b> Biological treatments studied improved asthma control after 3 months. Moreover, omalizumab and benralizumab showed an early improvement in ACT at first month. All treatments had a similar effect in FEV<sub>1</sub>, but highlight, patients with benralizumab had a lower value at baseline." @default.
- W4313019675 created "2023-01-05" @default.
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- W4313019675 date "2022-09-04" @default.
- W4313019675 modified "2023-09-28" @default.
- W4313019675 title "Early lung function and asthma control test score after different biological therapy in severe asthmatics patients in real-life" @default.
- W4313019675 doi "https://doi.org/10.1183/13993003.congress-2022.3918" @default.
- W4313019675 hasPublicationYear "2022" @default.
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