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• W4313039265 abstract "PreviousNext No AccessPharmacogenomics: Foundations, Competencies, and the Pharmacists’ Patient Care Process, 2nd EditionChapter 15: Infectious Diseases: Gentamicin/MT-RNR1 Casehttps://doi.org/10.21019/9781582123844.ch15Authors:Jacob D. Hoger, , PharmD/MS PGXDavid F. Kisor, BS, PharmD, FCP, RPHJacob D. HogerSearch for more papers by this author, David F. KisorSearch for more papers by this author SectionsAboutFull TextReferences ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Abstract:Mark S. is a 5'7, 140-lbs., 36-year-old male of East Asian ancestry with a history of chronic vape use (10+ years: when at home he typically puffs his vape pen every few minutes), presenting at the urgent care clinic affiliated with the regional hospital. He is complaining of extreme fatigue, fever, chills, shortness of breath, and a productive cough with discolored sputum. Mark states he felt like he was “getting a bug” a few days ago and thought that it would just go away, saying, “I normally get a cold a few times a year, but I have never had anything like this before. I took Tylenol® and Mucinex® DM, but nothing is helping.” During a physical assessment, the NP discovers bilateral wheezing, rales, and rhonchi. Mark’s O2 saturation is 88%, and the NP decides that it would be appropriate to admit Mark to the hospital with a diagnosis of pneumonia. Upon admission, chest x-ray shows bilateral infiltrates characteristic of pneumonia. Additionally, culture and susceptibility reports come back positive for Klebsiella pneumoniae. Due to Mark’s listed medication allergies, the attending hospitalist would like to start him on gentamicin. Prior to starting the medication, the hospitalist stops and ask you if ototoxicity is a concern in this patient, as he recently read something about MT-RNR1 and hearing loss with aminoglycoside exposure. References1. Joint Commission of Pharmacy Practitioners. Pharmacists’ Patient Care Process. https://jcpp.net/wp-content/uploads/2016/03/PatientCareProcess-with-supporting-organizations.pdf. Accessed January 5, 2022. Google Scholar, 2. Huddart R, Fohner AE, Whirl-Carrillo M, et al.. Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research. Clin Pharmacol Ther. 2019;105(5):1256–1262. doi:10.1002/cpt.1322, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465129/. Accessed January 6, 2021. Crossref, Medline, Google Scholar, 3. McDermott JH, Wolf J, Hoshitsuki K, et al.. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for the use of aminoglycosides based on MT-RNR1 genotype. Clin Pharmacol Ther. 2022;111(2):366–372. Crossref, Medline, Google Scholar, 4. McDermott JH, Wolf J, Hoshitsuki K, et al.. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for the use of aminoglycosides based on MT-RNR1 genotype. Supplemental information. https://cpicpgx.org/guidelines/cpic-guideline-for-aminoglycosides-and-mt-rnr1/. Accessed January 15, 2022. Google Scholar, 5. Whirl-Carrillo M, Huddart R, Gong L, et al.. An evidence-based framework for evaluating pharmacogenomics knowledge for personalized medicine [e-pub ahead of print]. Clin Pharmacol Ther. https://www.pharmgkb.org/page/citingPharmgkb. Accessed January 5, 2022. Google Scholar, 6. Whirl-Carrillo M, McDonagh EM, Hebert JM, et al.. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92(4):414–7. https://www.pharmgkb.org/page/citingPharmgkb. Accessed January 5, 2022. Crossref, Medline, Google Scholar, 7. Clinical Pharmacology, Internet Database. Tampa, FL: Elsevier. 2022. Available from: www.clinicalpharmacology.com. Accessed January 5, 2022. Google Scholar, 8. Gilbert DN, Chambers HF, Saag MS, et al.. The Sanford guide to antimicrobial therapy 2021. https://www.sanfordguide.com. Accessed January 4, 2022. Google Scholar, 9. DailyMed. Levofloxacin. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4438fed2-7ef5-488f-baa8-39bc65768d1d. Accessed date January 15, 2022. Google Scholar, PreviousNext Session Activity Recently Viewed Chapter 15: Infectious Diseases: Gentamicin/MT-RNR1 Case Jacob D. Hoger and David F. Kisor Recently Searched No search history FiguresReferencesRelatedDetails Published: 4 October 2022ISBN: 1-58212-384-5 Publisher American Pharmacists Association HistoryPublished: 4 October 2022 Citation Information Jacob D. Hoger and David F. Kisor, (2022), Chapter 15: Infectious Diseases: Gentamicin/MT-RNR1 Case, Pharmacogenomics: Foundations, Competencies, and the Pharmacists’ Patient Care Process, 2nd Edition https://doi.org/10.21019/9781582123844.ch15 Loading ..." @default.
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