FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313060504> ?p ?o ?g. }

• W4313060504 abstract "<b>Introduction:</b> Uncontrolled asthma can lead to severe exacerbations and reduced quality of life. Research has shown that the microbiome may be linked with asthma characteristics, however, its role in asthma control has not been explored. We aimed to investigate whether the microbiome could be used to discriminate between uncontrolled and controlled asthma in children. <b>Methods:</b> Saliva and feces samples were obtained from 143 children with moderate-to-severe asthma aged 6 to 17 years from the SysPharmPediA study [Abdel-Aziz and Neerincx et al. J Pers Med. 2021]. Patients were classified as controlled or uncontrolled asthmatics and their microbiome was compared using global (alpha/beta) diversity, differential abundance analysis (DAA, Analysis of compositions of microbiomes with bias correction) and machine learning (Recursive Ensemble Feature Selection (REFS)). <b>Results:</b> Global diversity and DAA did not find significant differences between controlled and uncontrolled asthmatics. REFS detected a set of taxa, including <i>Haemophilus</i> and <i>Veillonella</i>, differentiating uncontrolled and controlled asthma with an average classification accuracy of 81% (saliva) and 85% (feces). These taxa showed enrichment in taxa previously associated with inflammatory diseases for both sampling compartments, and with COPD for the saliva samples. <b>Conclusions:</b> Controlled and uncontrolled asthmatics could be differentiated in children based on their microbiome using machine learning, suggesting a link between asthma control and the microbiome. This suggests that the microbiome may be a potential target for a precision medicine approach to improve asthma control in children." @default.
• W4313060504 created "2023-01-06" @default.
• W4313060504 creator A5002159740 @default.
• W4313060504 creator A5010037722 @default.
• W4313060504 creator A5014191185 @default.
• W4313060504 creator A5017711541 @default.
• W4313060504 creator A5018535210 @default.
• W4313060504 creator A5020095733 @default.
• W4313060504 creator A5027733615 @default.
• W4313060504 creator A5031836075 @default.
• W4313060504 creator A5035635207 @default.
• W4313060504 creator A5042663571 @default.
• W4313060504 creator A5046184914 @default.
• W4313060504 creator A5052449132 @default.
• W4313060504 creator A5053206767 @default.
• W4313060504 creator A5054807456 @default.
• W4313060504 creator A5064684046 @default.
• W4313060504 creator A5065539575 @default.
• W4313060504 creator A5067149967 @default.
• W4313060504 creator A5074116493 @default.
• W4313060504 creator A5083965384 @default.
• W4313060504 creator A5084568384 @default.
• W4313060504 date "2022-09-04" @default.
• W4313060504 modified "2023-10-18" @default.
• W4313060504 title "Classifying asthma control using salivary and fecal microbiome in children with moderate to severe asthma: results from the SysPharmPediA study" @default.
• W4313060504 doi "https://doi.org/10.1183/13993003.congress-2022.4554" @default.
• W4313060504 hasPublicationYear "2022" @default.
• W4313060504 type Work @default.
• W4313060504 citedByCount "0" @default.
• W4313060504 crossrefType "proceedings-article" @default.
• W4313060504 hasAuthorship W4313060504A5002159740 @default.
• W4313060504 hasAuthorship W4313060504A5010037722 @default.
• W4313060504 hasAuthorship W4313060504A5014191185 @default.
• W4313060504 hasAuthorship W4313060504A5017711541 @default.
• W4313060504 hasAuthorship W4313060504A5018535210 @default.
• W4313060504 hasAuthorship W4313060504A5020095733 @default.
• W4313060504 hasAuthorship W4313060504A5027733615 @default.
• W4313060504 hasAuthorship W4313060504A5031836075 @default.
• W4313060504 hasAuthorship W4313060504A5035635207 @default.
• W4313060504 hasAuthorship W4313060504A5042663571 @default.
• W4313060504 hasAuthorship W4313060504A5046184914 @default.
• W4313060504 hasAuthorship W4313060504A5052449132 @default.
• W4313060504 hasAuthorship W4313060504A5053206767 @default.
• W4313060504 hasAuthorship W4313060504A5054807456 @default.
• W4313060504 hasAuthorship W4313060504A5064684046 @default.
• W4313060504 hasAuthorship W4313060504A5065539575 @default.
• W4313060504 hasAuthorship W4313060504A5067149967 @default.
• W4313060504 hasAuthorship W4313060504A5074116493 @default.
• W4313060504 hasAuthorship W4313060504A5083965384 @default.
• W4313060504 hasAuthorship W4313060504A5084568384 @default.
• W4313060504 hasConcept C126322002 @default.
• W4313060504 hasConcept C143121216 @default.
• W4313060504 hasConcept C203014093 @default.
• W4313060504 hasConcept C2776042228 @default.
• W4313060504 hasConcept C504460877 @default.
• W4313060504 hasConcept C60644358 @default.
• W4313060504 hasConcept C61716771 @default.
• W4313060504 hasConcept C71924100 @default.
• W4313060504 hasConcept C86803240 @default.
• W4313060504 hasConcept C89423630 @default.
• W4313060504 hasConceptScore W4313060504C126322002 @default.
• W4313060504 hasConceptScore W4313060504C143121216 @default.
• W4313060504 hasConceptScore W4313060504C203014093 @default.
• W4313060504 hasConceptScore W4313060504C2776042228 @default.
• W4313060504 hasConceptScore W4313060504C504460877 @default.
• W4313060504 hasConceptScore W4313060504C60644358 @default.
• W4313060504 hasConceptScore W4313060504C61716771 @default.
• W4313060504 hasConceptScore W4313060504C71924100 @default.
• W4313060504 hasConceptScore W4313060504C86803240 @default.
• W4313060504 hasConceptScore W4313060504C89423630 @default.
• W4313060504 hasLocation W43130605041 @default.
• W4313060504 hasOpenAccess W4313060504 @default.
• W4313060504 hasPrimaryLocation W43130605041 @default.
• W4313060504 hasRelatedWork W1545295393 @default.
• W4313060504 hasRelatedWork W2061925992 @default.
• W4313060504 hasRelatedWork W2074247784 @default.
• W4313060504 hasRelatedWork W2136253758 @default.
• W4313060504 hasRelatedWork W2402008476 @default.
• W4313060504 hasRelatedWork W2964430465 @default.
• W4313060504 hasRelatedWork W3029798277 @default.
• W4313060504 hasRelatedWork W3083673293 @default.
• W4313060504 hasRelatedWork W3199058129 @default.
• W4313060504 hasRelatedWork W4322724676 @default.
• W4313060504 isParatext "false" @default.
• W4313060504 isRetracted "false" @default.
• W4313060504 workType "article" @default.