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- W4313118147 abstract "Introduction. Contradictory information about the prognostic value of KRAS status in colorectal liver metastasis (CRLM) has been published. This study pursues to assess the influence of KRAS status in CRLM, specifically according to whether patients presented synchronous or metachronous metastasis Methods: Of the 154 patients who underwent hepatic resection for CRLM between January 2010 and August 2018, the KRAS status was available for 108 patients. Their clinical, surgical, and prognosis were analyzed based on metachronous or synchronous metastasis type. The Kaplan-Meier method was used to estimate overall survival and survival rates, and the log-rank test was used to compare the survival of the different patient groups. Results: For all patients with KRAS status available, the median overall survival (OS) was 49 months (95% CI 41.57-56.43 months). For the patients with metachronous metastasis (n=50), the wild type KRAS (wt-KRAS) group (n=21), the 3-years and 5-years OS was 75.6% and 51.6% respectively, vs. 56.9% 3-years and 38.4% 5-years OS in the mutated KRAS (mKRAS) group (n=29) (p=0.021). For the patients with synchronous metastasis (n=58), the wtKRAS group (n=36), the 3 year and 5-year OS were 71.2% and 46.7% respectively, vs. 38.8% 3-years and 8.3% 5-years OS in the mKRAS group (n=22) (p=0.001). Conclusion: In this study, the mKRAS status showed a significantly shorter overall survival between metachronous and synchronous metastasis. This biomarker should be considered as a survival predictor in the assessment of CRLM." @default.
- W4313118147 created "2023-01-06" @default.
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- W4313118147 date "2022-01-01" @default.
- W4313118147 modified "2023-09-30" @default.
- W4313118147 title "KRAS Status as Survival Predictor in Metachronous/Synchronous Colorectal Liver Metastasis" @default.
- W4313118147 doi "https://doi.org/10.1016/j.hpb.2022.05.151" @default.
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