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• W4313120735 abstract "Eukaryotic mRNAs are often first transcribed as precursor mRNAs (pre-mRNAs) that contain introns that must be removed. These introns are spliced out by a large molecular machine called the spliceosome. The major components of the spliceosome are small nuclear ribonucleoproteins made up of small nuclear RNAs and dozens of proteins. Spliceosomes form on RNA transcripts, recognize specific nucleotide sequences, and use basepairing interactions to bring catalytic groups together in order to remove introns. In humans, splicing is a central step in gene expression and alternative splicing greatly expands the coding capacity of the genome. Defects in splicing can lead to a number of diseases including cancers, blindness, or muscular atrophies." @default.
• W4313120735 created "2023-01-06" @default.
• W4313120735 creator A5029042204 @default.
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• W4313120735 date "2016-01-01" @default.
• W4313120735 modified "2023-10-01" @default.
• W4313120735 title "The Spliceosome and Pre-mRNA Splicing" @default.
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• W4313120735 doi "https://doi.org/10.1016/b978-0-12-821618-7.10052-5" @default.
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