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- W4313128654 abstract "Introduction: There are still many debates on the indication of surgical resection of IPMN. This study aims to validate malignant features detected in preoperative diagnosis of IPMN and establish selection criteria for appropriate surgical management. Method: Forty-eight IPMN patients who underwent surgical resection from January 2005 to December 2020 were enrolled. We assessed the correlation of factors with malignancy and searched for risk factors for invasive cancer. Results: Patients' characteristics; primary site (head/body and tail=28/20), type of IPMN (main pancreatic duct (MPD) type/ branched pancreatic duct (BD) type/ mixed type=9/20/19), malignancy (IPMA/high grade dysplasia/IPMC=17/11/10), jaundice (yes/no=1/47), diameter of main pancreatic duct >10mm (yes/no=17/31), enhanced nodule (yes/no=16/32), median cyst diameter >=30 mm (yes/no=20/28), thickened or contrast-enhanced septum (yes/no=19/29). Multivariate analysis showed the MPD diameter, enhanced nodule, and cyst size were indicators of malignancy. The malignancy rates of patients with two or more, one, and none of these factors were 100%/47%/24%, respectively. Multivariate analysis showed enhanced nodule and number of lesions (single or multiple) were indicators of invasive cancer. The invasive cancer rates of patients with two, one, and none of these factors were 80%/37%/7%, respectively. Conclusion: It was re-verified that the HRS factor and WF factors help indicate the presence of malignancy and invasiveness. Combinations of these findings will lead to more accurate predictions for malignancy and invasive cancer. Less invasive surgical procedures (limited lymphatic dissection, organ preservation) might be considered in patients with only a few HRS or WF factors." @default.
- W4313128654 created "2023-01-06" @default.
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- W4313128654 date "2022-01-01" @default.
- W4313128654 modified "2023-09-27" @default.
- W4313128654 title "Indicators of Malignancy and Invasive Cancer in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas" @default.
- W4313128654 doi "https://doi.org/10.1016/j.hpb.2022.05.619" @default.
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