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- W4313132571 abstract "<b>Background:</b> Women are underrepresented in studies on acute mountain sickness (AMS), high-altitude periodic breathing and effectiveness of preventive acetazolamide (AZA) therapy. <b>Methods:</b> We analyzed sex-specific altitude-effects observed in a randomized, placebo-controlled, double-blind trial of AZA in 345 healthy lowlanders >40y, 239 women (Furian NEJM Evidence 2022). Participants took 375mg/day AZA or placebo starting 24h before ascent to and while staying 2 days at 3100m. Main outcomes were sex-specific changes in nocturnal pulse oximetry (SpO2), apnea-hypopnea index (AHI) and incidence of AMS (Lake Louise score 2018 ≥3, including headache), at 3100m. <b>Results:</b> Among 119 women assigned to placebo, SpO2 (mean±SE 84±0%) and periodic breathing cycles (AHI 16.9±1.3/h) in night 1 at 3100m were lower compared to corresponding values in 55 men (SpO2 86±0%; AHI 28.3±1.9/h), despite similar baseline at 760m. Mean between-sexes difference(95%CI) in altitude-effects (women-men) in SpO2 was -1.4%(-2.4 to -0.3); AHI -10.7/h(-15.7 to -5.7). The sex-specific treatment effect of AZA was similar for improvement in SpO2 while AZA did not improve AHI in women but in men (difference men-women in treatment effect, -9.8/h [-16.8 to -2.7]). 25% of women and 8% of men developed AMS under placebo (P<0.05). AZA reduced AMS incidence in women to 20%, in men to 9% (both P=NS). <b>Conclusion:</b> This explorative study in lowlanders >40y may suggest sex-specific differences in altitude-induced hypoxemia, periodic breathing and incidence of AMS, as well as in the response to preventive AZA treatment. Randomized trials evaluating sex-specific altitude-effects are needed." @default.
- W4313132571 created "2023-01-06" @default.
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- W4313132571 date "2022-09-04" @default.
- W4313132571 modified "2023-09-28" @default.
- W4313132571 title "Sex-specific difference in health-related altitude-effects and effect of preventive acetazolamide treatment" @default.
- W4313132571 doi "https://doi.org/10.1183/13993003.congress-2022.2303" @default.
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