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- W4313133073 abstract "Abstract Dendritic cells (DC) play a central role in antitumor immune responses. Abnormal differentiation of DC and their inability to stimulate T cells are important factors in tumor escape from immune-system control. However, the mechanisms of this process remain elusive. Here, we have described one possible molecular mechanism that involves replacement linker histone H1°. A close association between expression of H1° and DC differentiation in vitro has been found. DC production in H1°-deficient mice was decreased significantly, whereas generation and function of macrophages, granulocytes, and lymphocytes appear to be normal. However, these mice had a significantly reduced response to vaccination with antigens. Tumor-derived factors considerably reduced h1° expression in hematopoietic progenitor cells. We have demonstrated that transcription factor NF-κB is involved actively in regulation of h1°. Thus, H1° histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1° expression." @default.
- W4313133073 created "2023-01-06" @default.
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- W4313133073 date "2002-08-01" @default.
- W4313133073 modified "2023-10-18" @default.
- W4313133073 title "H1° histone and differentiation of dendritic cells. A molecular target for tumor-derived factors" @default.
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- W4313133073 doi "https://doi.org/10.1189/jlb.72.2.285" @default.
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