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- W4313133936 abstract "Sedatives cause calmness, drowsiness, and reduced motor coordination, while hypnotics induce/maintain sleep. Due to the discovery of various classes of sedatives and hypnotics, modern medicine has seen a significant change in the management of insomnia, epilepsy, and anxiety. In vitro techniques to study the interaction of the test compound with GABAA, GABAB, Histaminergic, and adrenergic receptors in brain tissue will provide insight into the ‘selection of lead molecule.’ Various in-vivo techniques to study motor activity like the open field test, hole-board test, and method of intermittent observation provide information regarding the sedative efficacy of test molecules. Similarly, in-vivo tests like the incline phase test, chimney test, and Rotarod test delivers data for the effect of the test compound on muscle coordination. EEG registration in conscious cats, automated sleep system analysis in rats and experimental insomnia in rats provide data for the efficacy of test compounds on hypnotic activity. This chapter will review the various in-vitro, in-vivo behavioral methods and genetic models used to screen drugs with potential sedative and hypnotic activity." @default.
- W4313133936 created "2023-01-06" @default.
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- W4313133936 date "2022-01-01" @default.
- W4313133936 modified "2023-09-27" @default.
- W4313133936 title "Screening Methods for the Evaluation of Sedative-Hypnotics" @default.
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- W4313133936 doi "https://doi.org/10.1007/978-981-19-5343-9_17" @default.
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