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- W4313137377 abstract "There is a range of lung function trajectories throughout life, both above and below the normal range. The characteristics and associated factors of supranormal trajectories are still poorly understood. Here we explore supranormal lung function in different age bins within the LEAD study, a general population cohort (n=11423) in Vienna (Austria) ranging from 6-82 years of age (Breyer-Kohansal, R., et al. J Epidemiol 2019). We compared participants with normal (n=9839, FEV1; n=9871, FVC) or supranormal (n=383, FEV1; n=351, FVC) pre-bronchodilator (BD) FEV1 or FVC values (defined as > upper limit of normal - GLI equations). We found that: 1) the prevalence of supranormal pre-BD FEV1 and FVC values was 3.4% and 3.1%, respectively, and 5.3% and 3.2% after BD. About 50% of supranormal individuals have both increased FEV1 and FVC values; 2) these figures remained relatively stable over all age bins, except in participants > 60 years, in whom they increased to 5.1% and 4.2%, respectively; 3) supranormal spirometric values were consistently accompanied by higher static lung volumes and lower specific airway resistance, indicating physiological effects beyond spirometry; and, 4) Univariate analysis and multivariate regression identified female gender, body morphometry (shorter height, higher weight), body composition (lower fat, higher lean body mass), reduced respiratory symptoms, and less diabetes consistently and significantly associated with supranormal lung function. These results describe a proportion of the general population with supranormal FEV1 and/or FVC values through life span that seem to be associated with better health, thus supporting that spirometry is a global health marker (Agusti, A. et al. EJIM 2021)." @default.
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- W4313137377 date "2022-09-04" @default.
- W4313137377 modified "2023-10-07" @default.
- W4313137377 title "Supranormal lung function by age bins in the LEAD Study" @default.
- W4313137377 doi "https://doi.org/10.1183/13993003.congress-2022.913" @default.
- W4313137377 hasPublicationYear "2022" @default.
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