FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313137788> ?p ?o ?g. }

• W4313137788 endingPage "118" @default.
• W4313137788 startingPage "93" @default.
• W4313137788 abstract "The MHC lies within a small region of the 6th chromosome. Four loci are recognized (A, B, C and D). The genes at these loci control the expression of antigens found on the surface of nucleated cells. The presence of these cell surface antigens is determined by the use of specific antisera. Cell surface antigens expressed by the D locus are determined by the MLC reaction and by antisera to markers on B-lymphocytes, called B-cell alloantigens. The genes that control expression of cell surface antigens are either identical with or, more likely, located in close proximity to genes that control the production of serum complement components and various immunologic phenomena, such as graft-vs.-host reaction, delayed hypersensitivity, T-cell helper function, and T-cell suppressor function. The prevalence of certain cell surface antigens has been found to be increased in patients with certain diseases, including multiple sclerosis, insulin-dependent diabetes mellitus and psoriasis. In particular, there is a strong association between the presence of B27 cell surface antigen and ankylosing spondylitis, Reiter's disease and the spondylitis associated with psoriasis and inflammatory bowel disease. Much attention has been directed to the cell surface antigens of the A and B loci. The D locus antigens determined by MLC and by B-cell alloantigens may be more important as markers of disease susceptibility than those of the A and B loci. The D locus may be the immune response region. Associations with D locus markers have been made in rheumatoid arthritis, SLE, Sjögren's syndrome and JRA. In JRA, the greater prevalence of B27 cell surface antigen has been found to be associated with 2 particular subgroups. These include young males who develop peripheral arthritis and later spinal involvement compatible with ankylosing spondylitis and a second similar group with pauciarticular peripheral arthritis but without radiographic abnormalities of the sacroiliac joints or spine. The association of cell surface markers and disease susceptibility is one of the major discoveries of the century. Why do people get sick? Why do some people get sick while others do not? Causes of illness such as bacteria, viruses, carcinogens, and pollutants are omnipresent in our environment, but not all people exposed to environmental agents develop disease. Immune response may well determine whether we get sick or remain well. This response is surely controlled by genetic mechanisms. The process of understanding these mechanisms has only begun to unfold; this review has attempted to present the emerging picture." @default.
• W4313137788 created "2023-01-06" @default.
• W4313137788 creator A5064856626 @default.
• W4313137788 creator A5067999789 @default.
• W4313137788 creator A5073316716 @default.
• W4313137788 date "1979-01-01" @default.
• W4313137788 modified "2023-10-18" @default.
• W4313137788 title "HLA, Juvenile Rheumatoid Arthritis and Other Disease Associations" @default.
• W4313137788 cites W1492261264 @default.
• W4313137788 cites W1569549749 @default.
• W4313137788 cites W1618795914 @default.
• W4313137788 cites W185406357 @default.
• W4313137788 cites W1913266639 @default.
• W4313137788 cites W1966504829 @default.
• W4313137788 cites W1969756157 @default.
• W4313137788 cites W1970897847 @default.
• W4313137788 cites W1972226169 @default.
• W4313137788 cites W1973213176 @default.
• W4313137788 cites W1978084903 @default.
• W4313137788 cites W1979759634 @default.
• W4313137788 cites W1981009214 @default.
• W4313137788 cites W1987062435 @default.
• W4313137788 cites W1990676409 @default.
• W4313137788 cites W1990738930 @default.
• W4313137788 cites W1991036468 @default.
• W4313137788 cites W1992125803 @default.
• W4313137788 cites W1994206461 @default.
• W4313137788 cites W1995652317 @default.
• W4313137788 cites W1996113175 @default.
• W4313137788 cites W1996196642 @default.
• W4313137788 cites W1997010731 @default.
• W4313137788 cites W1999711712 @default.
• W4313137788 cites W2001766826 @default.
• W4313137788 cites W2001930223 @default.
• W4313137788 cites W2004584184 @default.
• W4313137788 cites W2007055191 @default.
• W4313137788 cites W2008157670 @default.
• W4313137788 cites W2018855162 @default.
• W4313137788 cites W2020469275 @default.
• W4313137788 cites W2021560174 @default.
• W4313137788 cites W2022697192 @default.
• W4313137788 cites W2025605079 @default.
• W4313137788 cites W2026424003 @default.
• W4313137788 cites W2030868603 @default.
• W4313137788 cites W2033185753 @default.
• W4313137788 cites W2038461192 @default.
• W4313137788 cites W2039088756 @default.
• W4313137788 cites W2039554067 @default.
• W4313137788 cites W2040581767 @default.
• W4313137788 cites W2040619773 @default.
• W4313137788 cites W2042167746 @default.
• W4313137788 cites W2042997258 @default.
• W4313137788 cites W2045294108 @default.
• W4313137788 cites W2053025681 @default.
• W4313137788 cites W2054223296 @default.
• W4313137788 cites W2056376954 @default.
• W4313137788 cites W2061887002 @default.
• W4313137788 cites W2066928105 @default.
• W4313137788 cites W2071578175 @default.
• W4313137788 cites W2077257587 @default.
• W4313137788 cites W2083972827 @default.
• W4313137788 cites W2084865373 @default.
• W4313137788 cites W2085282583 @default.
• W4313137788 cites W2087115229 @default.
• W4313137788 cites W2087347342 @default.
• W4313137788 cites W2090263003 @default.
• W4313137788 cites W2091943129 @default.
• W4313137788 cites W2093968470 @default.
• W4313137788 cites W2094338312 @default.
• W4313137788 cites W2100114764 @default.
• W4313137788 cites W2100365551 @default.
• W4313137788 cites W2105430744 @default.
• W4313137788 cites W2108794662 @default.
• W4313137788 cites W2115608169 @default.
• W4313137788 cites W2116599892 @default.
• W4313137788 cites W2120912287 @default.
• W4313137788 cites W2125173525 @default.
• W4313137788 cites W2127145766 @default.
• W4313137788 cites W2133980269 @default.
• W4313137788 cites W2146833788 @default.
• W4313137788 cites W2149326286 @default.
• W4313137788 cites W2149416050 @default.
• W4313137788 cites W2165317668 @default.
• W4313137788 cites W2167418901 @default.
• W4313137788 cites W2168507526 @default.
• W4313137788 cites W2289910292 @default.
• W4313137788 cites W2319469441 @default.
• W4313137788 cites W2327482527 @default.
• W4313137788 cites W2334622323 @default.
• W4313137788 cites W2336117795 @default.
• W4313137788 cites W2337429169 @default.
• W4313137788 cites W2338072779 @default.
• W4313137788 cites W2343664961 @default.
• W4313137788 cites W2404202049 @default.
• W4313137788 cites W2414477672 @default.
• W4313137788 cites W3091514540 @default.
• W4313137788 cites W3166505671 @default.
• W4313137788 cites W3166583523 @default.

• next