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- W4313142468 abstract "Recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) is a challenging disease with poor prognosis. Until recently, the EXTREME regimen (cis/carboplatin-5-fluorouracil-cetuximab) was standard treatment for R/M SCCHN considered sensitive to platinum. For patients pretreated with platinum, second-line options (methotrexate, cetuximab, or taxanes) have been unsatisfactory with a median survival of less than 6 months. Thanks to the CHECKMATE-141, KEYNOTE-012, KEYNOTE-055, and KEYNOTE-040 clinical trials, nivolumab and pembrolizumab, two PD-1 inhibitors, are approved in patients with R/M SCCHN who progress after platinum therapy. The results of KEYNOTE-048 also enabled pembrolizumab to be approved as first-line treatment for R/M SCCHN either as monotherapy or in combination with platinum and 5-fluorouracil. Different regimens are thus available and treatment selection should mainly be based on the PD-L1 expression combined positive score, patient symptoms, the need for rapid tumor shrinkage, possible autoimmune comorbidities, and contraindications to chemotherapies. While PD-1 inhibitors have shown impressive long-term responses in some R/M SCCHN patients, overall response rates remain moderate. To improve their efficacy, different strategies are under investigation including immunotherapy combinations and combinations with targeted therapies or other treatment modalities." @default.
- W4313142468 created "2023-01-06" @default.
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- W4313142468 date "2022-01-01" @default.
- W4313142468 modified "2023-10-16" @default.
- W4313142468 title "Drug Targets and Strategies in the Clinical Development of Immunotherapy for Head and Neck Cancer" @default.
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- W4313142468 doi "https://doi.org/10.1007/13905_2022_27" @default.
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