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- W4313142860 abstract "<b>Rationale:</b> In randomized controlled trials, CPAP is reported as lowering 24-hour blood pressure (BP) with a mean effect size of 2 mmHg. These studies are limited by a median follow-up of less than 6 months. Whether initial BP response during the first months of CPAP treatment is translating in a reduction of long-term cardiovascular events and mortality is unknown. <b>Methods:</b> Observational study addressing long term hard cardio-metabolic outcomes and all-cause mortality in a well-defined population of 241 patients previously included in the AgirSASadom randomized, parallel, controlled trial [Pépin JL, et al. Thorax 2016;71:726–733] designed to assess whether fixed-pressure CPAP was superior to autoadjusted CPAP in reducing blood BP [Baseline evaluation: June 2010-October 2012]. Multivariable survival Cox and logistic regression models were performed. <b>Results:</b> 61 cardiovascular events occurred during a mean follow-up of 113 months (IQR [102;124]) giving an incidence of 26 for 1000 person/year. 21 (8.7%) patients died. BP phenotype at baseline (i.e. office and 24-hour BP) was a strong predictor of incident cardiometabolic events and mortality (p<0.01) whereas initial response during the four months after CPAP initiation was not related to outcomes. A CPAP adherence above 4 hours per night reduced all-cause mortality and occurrence of long-term cardiovascular events (OR: 0.41 [0.21; 0.77], p=0.01). <b>Conclusion:</b> Independently of initial blood pressure response, long term CPAP adherence is one of the prerequisites for reducing the rate of incident events and mortality." @default.
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- W4313142860 date "2022-09-04" @default.
- W4313142860 modified "2023-10-01" @default.
- W4313142860 title "Long term outcomes in CPAP-treated sleep apnea patients: Impact of blood pressure responses after CPAP initiation and treatment adherence" @default.
- W4313142860 doi "https://doi.org/10.1183/13993003.congress-2022.1631" @default.
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