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- W4313144859 abstract "Glioblastomas (GBM) are the most frequent and malignant human brain tumors. Although GBM incidence is low, it is almost always lethal. Standard treatment for GBM include surgery, irradiation, and temozolomide (TMZ) chemotherapy; however, these therapies are limited in efficacy due to failure of drug delivery through the blood-brain barrier, high rates of recurrence, overall resistance to therapy, and devastating neurological deterioration. There is a need for novel therapeutic intervention to prevent side effects and enhance prognostic outcome. It has been reported that reactive oxygen species (ROS) are involved in different signaling pathways to control cellular stability, where cellular redox impairment is strictly related to tumorigenesis. Different ROS can exert different biological effects, and cancer cells, due their high basal metabolic rate, are more susceptible, when compared to normal cells, to therapeutic agents targeting the cellular redox status. Therefore, anticancer drugs that destroy malignant cells driving the formation of intracellular ROS, such as photodynamic therapy (PDT), can be developed to treat GBM. PDT is based on the cascade of synergistic effects between light, photosensitizer (PS), and oxygen, which greatly favor the spatiotemporal control of the treatment. Due to the high infiltrative nature of GBM, poor biodistribution of cancer drugs are seen. However, experiments have shown that adult stem cells have an uncanny ability to home to cancer cells and tumors. Therefore, along with the means of reaching the tumor site, a noninvasive therapeutic modality with little to no side effects such as PDT can be used to potentially treat GBM." @default.
- W4313144859 created "2023-01-06" @default.
- W4313144859 creator A5012382625 @default.
- W4313144859 creator A5015281771 @default.
- W4313144859 creator A5067892839 @default.
- W4313144859 creator A5072586638 @default.
- W4313144859 date "2022-01-01" @default.
- W4313144859 modified "2023-09-27" @default.
- W4313144859 title "Adipose-Derived Stem Cells as Photodynamic Therapeutic Carriers for Treatment of Glioblastoma Exploiting Reactive Oxygen Species" @default.
- W4313144859 cites W1512723684 @default.
- W4313144859 cites W1532262338 @default.
- W4313144859 cites W1731631895 @default.
- W4313144859 cites W1873944504 @default.
- W4313144859 cites W1933880153 @default.
- W4313144859 cites W1964350921 @default.
- W4313144859 cites W1968628080 @default.
- W4313144859 cites W1980073077 @default.
- W4313144859 cites W1980441719 @default.
- W4313144859 cites W1988432563 @default.
- W4313144859 cites W2000562577 @default.
- W4313144859 cites W2000718634 @default.
- W4313144859 cites W2008638092 @default.
- W4313144859 cites W2012848985 @default.
- W4313144859 cites W2041149058 @default.
- W4313144859 cites W2047059507 @default.
- W4313144859 cites W2048220702 @default.
- W4313144859 cites W2048563197 @default.
- W4313144859 cites W2056056906 @default.
- W4313144859 cites W2068052133 @default.
- W4313144859 cites W2077626129 @default.
- W4313144859 cites W2088138454 @default.
- W4313144859 cites W2093691821 @default.
- W4313144859 cites W2095085916 @default.
- W4313144859 cites W2109172505 @default.
- W4313144859 cites W2118342895 @default.
- W4313144859 cites W2118852328 @default.
- W4313144859 cites W2119775467 @default.
- W4313144859 cites W2123109602 @default.
- W4313144859 cites W2125987139 @default.
- W4313144859 cites W2126532541 @default.
- W4313144859 cites W2133899314 @default.
- W4313144859 cites W2153159003 @default.
- W4313144859 cites W2160666689 @default.
- W4313144859 cites W2217323949 @default.
- W4313144859 cites W2229105716 @default.
- W4313144859 cites W2268783183 @default.
- W4313144859 cites W2320574135 @default.
- W4313144859 cites W2405695982 @default.
- W4313144859 cites W2461570210 @default.
- W4313144859 cites W2466871913 @default.
- W4313144859 cites W2475874939 @default.
- W4313144859 cites W2512891139 @default.
- W4313144859 cites W2526184544 @default.
- W4313144859 cites W2526727674 @default.
- W4313144859 cites W2530349582 @default.
- W4313144859 cites W2535579064 @default.
- W4313144859 cites W2560207601 @default.
- W4313144859 cites W2590947287 @default.
- W4313144859 cites W2606686841 @default.
- W4313144859 cites W2727471603 @default.
- W4313144859 cites W2758783177 @default.
- W4313144859 cites W2771830523 @default.
- W4313144859 cites W2784657658 @default.
- W4313144859 cites W2788640168 @default.
- W4313144859 cites W2793453538 @default.
- W4313144859 cites W2795121593 @default.
- W4313144859 cites W2796781998 @default.
- W4313144859 cites W2797725119 @default.
- W4313144859 cites W2801067660 @default.
- W4313144859 cites W2884145325 @default.
- W4313144859 cites W2887170366 @default.
- W4313144859 cites W2887887037 @default.
- W4313144859 cites W2888616905 @default.
- W4313144859 cites W2892568803 @default.
- W4313144859 cites W2894172877 @default.
- W4313144859 cites W2922523158 @default.
- W4313144859 cites W2923614429 @default.
- W4313144859 cites W2944443783 @default.
- W4313144859 cites W2946284807 @default.
- W4313144859 cites W2954729387 @default.
- W4313144859 cites W2960989010 @default.
- W4313144859 cites W2969159587 @default.
- W4313144859 cites W2987957098 @default.
- W4313144859 cites W3002274740 @default.
- W4313144859 cites W3005689864 @default.
- W4313144859 cites W3006454840 @default.
- W4313144859 cites W3010423729 @default.
- W4313144859 cites W3011552041 @default.
- W4313144859 cites W3012346661 @default.
- W4313144859 cites W3021826369 @default.
- W4313144859 cites W3032994716 @default.
- W4313144859 cites W3045155083 @default.
- W4313144859 cites W3047194866 @default.
- W4313144859 cites W3089900664 @default.
- W4313144859 cites W3123368520 @default.
- W4313144859 cites W3136113031 @default.
- W4313144859 cites W3159823206 @default.
- W4313144859 doi "https://doi.org/10.1007/978-981-16-5422-0_205" @default.