Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313155008> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313155008 abstract "There is a growing interest in elucidating the mechanisms that govern atherosclerotic plaque instability, which has so far highlighted the role of dysregulations in lipid, carbohydrate, and amino acid metabolism. However, where these impairments occur in a plaque has yet to be revealed. This is critically important because lipid deposition, cell composition, and matrix stiffness are heterogeneous throughout human atheromas, particularly in regions of the fibrous cap and near the necrotic core. Furthermore, lesional cells are constantly bombarded with various intrinsic and extrinsic metabolic insults that influence cell phenotype. Mass spectrometry imaging (MSI) is a powerful technology for the visualization of the spatial localization and relative abundance of hundreds to thousands of analytes in thin tissue sections without the need for a priori knowledge of analytes present in the tissue. Imaging is performed using matrix-assisted laser desorption/ionization (MALDI) to interrogate small areas from a tissue surface after the addition of a chemical matrix to the section which serves to extract, co-crystallize, and ionize molecules from the sample. In the present study, we performed MSI of late-stage, stable and vulnerable human atherosclerotic plaques using MALDI-MSI to visualize the distribution of metabolites in the fibrous cap and necrotic core. This platform was able to identify 856 metabolites assigned with chemical formulas. We were then able to confidently annotate 189 metabolites using a data filtering system whereby we queried detected and quantified metabolites from the Human Metabolome Database (HMDB). Coupled with RNAseq examining human stable and unstable atheromas, we identified differences in pathways related to nitric oxide metabolism, collagen catabolism, arginine metabolism, tryptophan metabolism, lipid metabolism, and reactive oxygen species. This work represents the first study to begin defining an atlas of metabolic pathways involved in plaque destabilization in human atherosclerosis. We anticipate this work will be a valuable resource for the scientific community and will ultimately open new avenues of research in cardiovascular disease." @default.
- W4313155008 created "2023-01-06" @default.
- W4313155008 creator A5028708071 @default.
- W4313155008 creator A5034399354 @default.
- W4313155008 creator A5038686753 @default.
- W4313155008 creator A5046125196 @default.
- W4313155008 date "2022-05-01" @default.
- W4313155008 modified "2023-09-26" @default.
- W4313155008 title "Abstract 441: Spatially Resolved Metabolites In Stable And Vulnerable Human Atherosclerotic Plaques Identified By Mass Spectrometry Imaging" @default.
- W4313155008 doi "https://doi.org/10.1161/atvb.42.suppl_1.441" @default.
- W4313155008 hasPublicationYear "2022" @default.
- W4313155008 type Work @default.
- W4313155008 citedByCount "0" @default.
- W4313155008 crossrefType "journal-article" @default.
- W4313155008 hasAuthorship W4313155008A5028708071 @default.
- W4313155008 hasAuthorship W4313155008A5034399354 @default.
- W4313155008 hasAuthorship W4313155008A5038686753 @default.
- W4313155008 hasAuthorship W4313155008A5046125196 @default.
- W4313155008 hasConcept C101092202 @default.
- W4313155008 hasConcept C10390740 @default.
- W4313155008 hasConcept C106487976 @default.
- W4313155008 hasConcept C12554922 @default.
- W4313155008 hasConcept C135870905 @default.
- W4313155008 hasConcept C142724271 @default.
- W4313155008 hasConcept C150394285 @default.
- W4313155008 hasConcept C162356407 @default.
- W4313155008 hasConcept C162711632 @default.
- W4313155008 hasConcept C178790620 @default.
- W4313155008 hasConcept C185592680 @default.
- W4313155008 hasConcept C21565614 @default.
- W4313155008 hasConcept C24066741 @default.
- W4313155008 hasConcept C43617362 @default.
- W4313155008 hasConcept C55493867 @default.
- W4313155008 hasConcept C71924100 @default.
- W4313155008 hasConcept C75280812 @default.
- W4313155008 hasConcept C86803240 @default.
- W4313155008 hasConceptScore W4313155008C101092202 @default.
- W4313155008 hasConceptScore W4313155008C10390740 @default.
- W4313155008 hasConceptScore W4313155008C106487976 @default.
- W4313155008 hasConceptScore W4313155008C12554922 @default.
- W4313155008 hasConceptScore W4313155008C135870905 @default.
- W4313155008 hasConceptScore W4313155008C142724271 @default.
- W4313155008 hasConceptScore W4313155008C150394285 @default.
- W4313155008 hasConceptScore W4313155008C162356407 @default.
- W4313155008 hasConceptScore W4313155008C162711632 @default.
- W4313155008 hasConceptScore W4313155008C178790620 @default.
- W4313155008 hasConceptScore W4313155008C185592680 @default.
- W4313155008 hasConceptScore W4313155008C21565614 @default.
- W4313155008 hasConceptScore W4313155008C24066741 @default.
- W4313155008 hasConceptScore W4313155008C43617362 @default.
- W4313155008 hasConceptScore W4313155008C55493867 @default.
- W4313155008 hasConceptScore W4313155008C71924100 @default.
- W4313155008 hasConceptScore W4313155008C75280812 @default.
- W4313155008 hasConceptScore W4313155008C86803240 @default.
- W4313155008 hasIssue "Suppl_1" @default.
- W4313155008 hasLocation W43131550081 @default.
- W4313155008 hasOpenAccess W4313155008 @default.
- W4313155008 hasPrimaryLocation W43131550081 @default.
- W4313155008 hasRelatedWork W2048919949 @default.
- W4313155008 hasRelatedWork W2049554068 @default.
- W4313155008 hasRelatedWork W2053777062 @default.
- W4313155008 hasRelatedWork W2094044157 @default.
- W4313155008 hasRelatedWork W2113325155 @default.
- W4313155008 hasRelatedWork W2585846515 @default.
- W4313155008 hasRelatedWork W3004812484 @default.
- W4313155008 hasRelatedWork W3088880169 @default.
- W4313155008 hasRelatedWork W3203162923 @default.
- W4313155008 hasRelatedWork W4200376906 @default.
- W4313155008 hasVolume "42" @default.
- W4313155008 isParatext "false" @default.
- W4313155008 isRetracted "false" @default.
- W4313155008 workType "article" @default.