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- W4313160218 abstract "<b>Rationale:</b> Lung volumes identify the “susceptible smokers” who progress to develop spirometric COPD, which seems to be a heterogenous process with staggered onset of different pathologic mechanisms in early disease. <b>Objective:</b> Determine the radiographic patterns of emphysema and airway disease among susceptible smokers. <b>Methods:</b> We categorized smokers with preserved spirometry (GOLD-0) in the COPDGene cohort (N=2,159) based on tertiles (low, intermediate, and high) of baseline lung volumes (TLC, FRC, or FRC/TLC), and examined the differential patterns of change in spirometry and the associated prevalence of CT-measured emphysema (Insp<sub>-950</sub>; PRM<sup>Emphysema</sup>) and airway disease (EXP<sub>-856</sub>; PRM<sup>Air Trapping</sup>; Pi10). <b>Results:</b> The pattern of spirometric change differed when participants were categorized by TLC versus FRC/TLC: those in high TLC tertile showed stable FEV1 but enlarging FVC while those in high FRC/TLC tertile showed decline in both FEV<sub>1</sub> and FVC. Compared to those with high TLC, those with high FRC/TLC had lesser emphysema but greater air trapping, more respiratory symptoms, more decline in physical activity, higher likelihood of progressing to more severe spirometric disease, and a trend towards more severe exacerbations. <b>Discussion:</b> Lung volumes identify distinct phenotypes in early disease among susceptible smokers and predict the rate of spirometric disease progression and the severity of symptoms in early COPD." @default.
- W4313160218 created "2023-01-06" @default.
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- W4313160218 date "2022-09-04" @default.
- W4313160218 modified "2023-09-26" @default.
- W4313160218 title "Lung volumes differentiate the predominance of emphysema versus airway disease phenotype in early COPD" @default.
- W4313160218 doi "https://doi.org/10.1183/13993003.congress-2022.4674" @default.
- W4313160218 hasPublicationYear "2022" @default.
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