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- W4313160730 abstract "Significant advances have been made in cancer immunotherapy in recent years. However, few patients with ovarian cancer have benefited from immunotherapy and the prognosis is usually poor. A major mechanism by which cancer is rarely detected by immune cells is the downregulation of major histocompatibility complex class I (MHC-I), which leads to reduced recognition and cytotoxicity of cytotoxic T cells. What we were investigating is to find regulators that can modulate the expression of MHC-I molecules in ovarian cancer. Improving MHC-I expression may help patients to have a good prognosis. By analyzing tumoral transcriptional sequencing data and combined with clinical effects, we identified STAT1 as a potential MHC-I regulator in ovarian cancer cells. The “wet-lab” experiments confirmed the role of STAT1 in the expression of MHC-I molecules. Our study suggested that STAT1 could be a target to promote immunotherapeutic response by promoting the expression of MHC-I molecule in ovarian cancer cells." @default.
- W4313160730 created "2023-01-06" @default.
- W4313160730 creator A5066785477 @default.
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- W4313160730 date "2022-08-19" @default.
- W4313160730 modified "2023-10-17" @default.
- W4313160730 title "STAT1 Regulates the Expression of MHC-I Class Molecules in Ovarian Cancer" @default.
- W4313160730 cites W2013151542 @default.
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- W4313160730 doi "https://doi.org/10.1145/3563737.3563746" @default.
- W4313160730 hasPublicationYear "2022" @default.
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