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- W4313161161 endingPage "26" @default.
- W4313161161 startingPage "3" @default.
- W4313161161 abstract "The pituitary gland has a relatively simple organization despite its central role as chef d'orchestre of the endocrine system. Indeed, the glandular portion of the pituitary comprised of the anterior and intermediate lobes contains six secretory cell types, each dedicated to the production of a different hormone. Long thought to be a random patchwork of cells, we are just now discovering that pituitary cells are organized in 3D structures and that the tissue develops following a precise stepwise plan. As for most tissues and organs, numerous signaling pathways are involved in pituitary organogenesis but it is mostly the discovery of regulatory transcription factors that has provided insight into mechanisms of pituitary development. Genetic analyses of the genes encoding these transcription factors have defined mechanisms for the formation of Rathke's pouch, the pituitary anlage, and for expansion and differentiation of this simple epithelium into a complex network of endocrine cells that produce hormones while integrating complex inputs from the hypothalamus and blood stream. The understanding of normal developmental processes provides novel insight into mechanisms of pathogenesis: for example, critical regulators of pituitary cell differentiation become the cause of hormone deficiencies when their genes carry mutations. This chapter surveys current notions of pituitary development highlighting the impact of this knowledge on understanding pituitary pathologies as well as identifying the challenges and gaps for the future." @default.
- W4313161161 created "2023-01-06" @default.
- W4313161161 creator A5002365357 @default.
- W4313161161 creator A5040102740 @default.
- W4313161161 date "2022-01-01" @default.
- W4313161161 modified "2023-09-26" @default.
- W4313161161 title "Pituitary Development" @default.
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