Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313169213> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4313169213 abstract "Abstract Introduction One in 5 people have a suboptimal weight-loss (WL) response to bariatric surgery. The causes are unclear, but patients report resumed hunger and increased food intake, eating behaviours driven by the orexigenic hormone, ghrelin. This proof-of-concept study aimed to evaluate the impact of reducing circulating acyl-ghrelin, the biologically active isoform, on appetite and energy intake in people with suboptimal WL and aberrant ghrelin profile after bariatric surgery. Methods Thirty-five patients with <20%WL from 12 months after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) and aberrant circulating ghrelin profile underwent 10 days of treatment with a novel, highly-selective ghrelin o-acyltransferase inhibitor, GLWL-01, and placebo. The primary endpoint was within-person change in ad libitum energy intake during a test meal on day 10. Secondary endpoints assessed subjective appetite, food cravings, macronutrient intake, gut hormones, cardiometabolic profile and body composition. Ethical approval was obtained. Results Thirty-one participants (26 RYGB, 9 SG) completed both cycles. GLWL-01 produced a 58.9±27.2% decrease in fasting plasma acyl-ghrelin and 29.3±27.1% increase in desacyl-ghrelin after 10 days. Marked reduction in subjective hunger, food cravings and hedonic influence on appetite was observed with GLWL-01, however objective appetite measures – ad libitum and free-living energy intake – did not change. Circulating levels of cardiovascular risk-conferring lipoproteins significantly improved and no adverse impact on glycaemic control was observed. Conclusion Pharmacological modulation of the ghrelin system may be used as part of a personalised therapeutic approach to optimise clinical outcomes in patients with suboptimal WL after bariatric surgery. Take-home message This first-in-human mechanistic study shows that pharmacological modulation of the ghrelin system is a promising therapeutic strategy for maximising weight loss response to bariatric surgery." @default.
- W4313169213 created "2023-01-06" @default.
- W4313169213 creator A5007504985 @default.
- W4313169213 creator A5014176628 @default.
- W4313169213 creator A5015470282 @default.
- W4313169213 creator A5026158353 @default.
- W4313169213 creator A5027448769 @default.
- W4313169213 creator A5031558685 @default.
- W4313169213 creator A5034959534 @default.
- W4313169213 creator A5058755190 @default.
- W4313169213 creator A5060016143 @default.
- W4313169213 creator A5067069210 @default.
- W4313169213 creator A5085481226 @default.
- W4313169213 date "2022-07-22" @default.
- W4313169213 modified "2023-10-16" @default.
- W4313169213 title "O106 Maximising the benefits of bariatric surgery through targeting ghrelin: a randomised, double-blind, placebo-controlled crossover study in people with suboptimal weight loss after bariatric surgery" @default.
- W4313169213 doi "https://doi.org/10.1093/bjs/znac242.106" @default.
- W4313169213 hasPublicationYear "2022" @default.
- W4313169213 type Work @default.
- W4313169213 citedByCount "0" @default.
- W4313169213 crossrefType "journal-article" @default.
- W4313169213 hasAuthorship W4313169213A5007504985 @default.
- W4313169213 hasAuthorship W4313169213A5014176628 @default.
- W4313169213 hasAuthorship W4313169213A5015470282 @default.
- W4313169213 hasAuthorship W4313169213A5026158353 @default.
- W4313169213 hasAuthorship W4313169213A5027448769 @default.
- W4313169213 hasAuthorship W4313169213A5031558685 @default.
- W4313169213 hasAuthorship W4313169213A5034959534 @default.
- W4313169213 hasAuthorship W4313169213A5058755190 @default.
- W4313169213 hasAuthorship W4313169213A5060016143 @default.
- W4313169213 hasAuthorship W4313169213A5067069210 @default.
- W4313169213 hasAuthorship W4313169213A5085481226 @default.
- W4313169213 hasBestOaLocation W43131692131 @default.
- W4313169213 hasConcept C118303440 @default.
- W4313169213 hasConcept C126322002 @default.
- W4313169213 hasConcept C134018914 @default.
- W4313169213 hasConcept C142724271 @default.
- W4313169213 hasConcept C170493617 @default.
- W4313169213 hasConcept C204787440 @default.
- W4313169213 hasConcept C27081682 @default.
- W4313169213 hasConcept C2777205416 @default.
- W4313169213 hasConcept C2778345441 @default.
- W4313169213 hasConcept C2778586554 @default.
- W4313169213 hasConcept C2779357093 @default.
- W4313169213 hasConcept C3019402062 @default.
- W4313169213 hasConcept C511355011 @default.
- W4313169213 hasConcept C544821477 @default.
- W4313169213 hasConcept C71315377 @default.
- W4313169213 hasConcept C71924100 @default.
- W4313169213 hasConcept C75908981 @default.
- W4313169213 hasConcept C90924648 @default.
- W4313169213 hasConcept C93984277 @default.
- W4313169213 hasConceptScore W4313169213C118303440 @default.
- W4313169213 hasConceptScore W4313169213C126322002 @default.
- W4313169213 hasConceptScore W4313169213C134018914 @default.
- W4313169213 hasConceptScore W4313169213C142724271 @default.
- W4313169213 hasConceptScore W4313169213C170493617 @default.
- W4313169213 hasConceptScore W4313169213C204787440 @default.
- W4313169213 hasConceptScore W4313169213C27081682 @default.
- W4313169213 hasConceptScore W4313169213C2777205416 @default.
- W4313169213 hasConceptScore W4313169213C2778345441 @default.
- W4313169213 hasConceptScore W4313169213C2778586554 @default.
- W4313169213 hasConceptScore W4313169213C2779357093 @default.
- W4313169213 hasConceptScore W4313169213C3019402062 @default.
- W4313169213 hasConceptScore W4313169213C511355011 @default.
- W4313169213 hasConceptScore W4313169213C544821477 @default.
- W4313169213 hasConceptScore W4313169213C71315377 @default.
- W4313169213 hasConceptScore W4313169213C71924100 @default.
- W4313169213 hasConceptScore W4313169213C75908981 @default.
- W4313169213 hasConceptScore W4313169213C90924648 @default.
- W4313169213 hasConceptScore W4313169213C93984277 @default.
- W4313169213 hasIssue "Supplement_4" @default.
- W4313169213 hasLocation W43131692131 @default.
- W4313169213 hasOpenAccess W4313169213 @default.
- W4313169213 hasPrimaryLocation W43131692131 @default.
- W4313169213 hasRelatedWork W1924502839 @default.
- W4313169213 hasRelatedWork W1994453695 @default.
- W4313169213 hasRelatedWork W2018225634 @default.
- W4313169213 hasRelatedWork W2030322163 @default.
- W4313169213 hasRelatedWork W2034697008 @default.
- W4313169213 hasRelatedWork W2060936747 @default.
- W4313169213 hasRelatedWork W2061195830 @default.
- W4313169213 hasRelatedWork W2063052824 @default.
- W4313169213 hasRelatedWork W2112202133 @default.
- W4313169213 hasRelatedWork W2141804323 @default.
- W4313169213 hasVolume "109" @default.
- W4313169213 isParatext "false" @default.
- W4313169213 isRetracted "false" @default.
- W4313169213 workType "article" @default.