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- W4313170987 abstract "Allolobophora caliginosa, an indigenous earthworm of Egypt, has been widely utilized in the pharmaceutical industry because it has many therapeutic properties. These therapeutic properties may be attributed to the earthworm's coelomic fluid being a promising reservoir of bioactive secondary metabolites. Hence, the current study was intended to identify the bioactive constituents and the biological activities of Allolobophora caliginosa coelomic fluid (ACCF). The active constituents, total protein content, and amino acid profile of ACCF were identified using high-performance liquid chromatography, the Biuret method, and an amino acid analyzer. The antioxidant, anti-inflammatory, and cytotoxicity activities of ACCF were evaluated using in vitro assays. The analgesic effect was evaluated using the writhing and hot plate assays. The antipyretic potency was determined using Brewer's yeast-induced pyrexia assay. Various active phenolic and flavonoid constituents and a considerable amount of essential and non-essential amino acids, were found in ACCF. The current study clarified that ACCF exhibited dose-dependent radical scavenging and potent anti-inflammatory activities. Furthermore, the proliferation of HepG2 could be inhibited by ACCF with the IC50 value of 145.99 µg/ml. The present findings revealed that ACCF showed amazing peripherally and centrally analgesic and antipyretic potencies. ACCF has various secondary metabolites that were likely to act synergistically to produce the observed biological activities. Thus, it can be served as a promising alternative natural compound for the prophylaxis or treatment of infectious disorders." @default.
- W4313170987 created "2023-01-06" @default.
- W4313170987 date "2022-06-05" @default.
- W4313170987 modified "2023-10-01" @default.
- W4313170987 title "A Coelomic Fluid of Allolobophora caliginosa as Novel Prospects for Medicinal Antioxidants, Anti-inflammatory, Antiproliferative, Analgesics, and Antipyretics" @default.
- W4313170987 doi "https://doi.org/10.33263/briac133.209" @default.
- W4313170987 hasPublicationYear "2022" @default.
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