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- W4313171888 abstract "<b>Introduction:</b> The 6th World Symposium of PH (WSPH) suggested a new haemodynamic definition of precapillary PH: mPAP >20 mmHg and PVR ≥3 WU. There are few published data regarding the impact of these changes on patient diagnoses and of outcomes in patients with different PVR thresholds. <b>Methods:</b> The ASPIRE registry was interrogated to identify systemic sclerosis (SSc) patients who had undergone baseline right heart catheterisation between 2000-2020. <b>Results:</b> 652 patients with mPAP >20 mmHg and PAWP ≤15 mmHg were identified. Using the previous criteria (mPAP ≥25mmHg and PVR >3 WU), 503 patients had precapillary PH. Only 13 further patients met the 6th WSPH criteria while 113 extra patients (n=616) were diagnosed with precapillary PH if criteria of mPAP >20 mmHg and PVR ≥2 WU were used. Survival in patients with PVR 2-3 WU was significantly worse than in patients with PVR <2 WU, but was not significantly different to those with PVR 3-4 WU. <b>Conclusions:</b> The proposed 6th WSPH haemodynamic criteria identify only a small number of additional patients with precapillary PH. The use of a PVR threshold of 2 WU identifies a much larger number of extra patients. Survival of patients with PVR 2-3 WU does not significantly differ from those with a PVR 3-4 WU. These data support the use of a PVR threshold of 2 rather than 3 WU in the diagnosis of precapillary PH." @default.
- W4313171888 created "2023-01-06" @default.
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- W4313171888 date "2022-09-04" @default.
- W4313171888 modified "2023-09-28" @default.
- W4313171888 title "New diagnostic criteria and PVR thresholds in SSc-associated PH: Insights from the ASPIRE registry" @default.
- W4313171888 doi "https://doi.org/10.1183/13993003.congress-2022.1295" @default.
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