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• W4313174952 abstract "Reactive oxygen species (ROS) play an essential role in physiological functions as an intracellular signal-regulating molecule as well as in the pathophysiology condition of an organism like cancer, etc. In cancer, the critical characteristic that distinguishes it from normal healthy cells is the elevated level of ROS and extra dependence on its antioxidant defense system. Further, these elevated level of ROS has an essential role in cancer initiation, progression, and maintenance. Hence, the behavior of ROS in cancer cells has become a crucial target in cancer therapeutics. The ROS-modulating approaches in cancer treatment might be either lowering the level of ROS for preventing oncogene activation (antioxidative-based therapy) or increasing the ROS above the susceptible level for selective killing of cancer cells (Pro-oxidative). Among both, pro-oxidative is most preferred and commonly practiced clinically. Numerous numbers of pro-oxidative agents have been recognized, which are capable of increasing the ROS level above the susceptible limit either directly via generation of ROS or indirectly by inhibiting the antioxidant defense system of the cells. However, the clinical success of pro-oxidative agents is hindered due to their cytotoxicity effects on healthy tissues and their poor solubility such as observed in doxorubicin. Thanks to recent advancements in the field of nanotechnology, where nanomaterials can deliver these active molecules to the target sites, such undesirable cytotoxicity is minimized. Further, these nanomaterials also have been used for co-delivery of agents, such as containing ROS-modulation agents as well as the agents with other abilities resulting in better therapeutic efficacy. Moreover, the nanoparticles having ROS-regulating properties such as cerium oxide or zinc oxide (photosensitizers) as well as protein-based nanoparticles contribute to the development of a new era of therapeutic avenue providing a combinational therapy where nanoparticles deliver the chemotherapeutical drugs to the targeted site along with its ROS-modulating effect giving high therapeutic efficacy by killing cancer cell along with the potential to protect the healthy cells." @default.
• W4313174952 created "2023-01-06" @default.
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• W4313174952 date "2022-01-01" @default.
• W4313174952 modified "2023-10-01" @default.
• W4313174952 title "A Detailed Overview of ROS-Modulating Approaches in Cancer Treatment" @default.
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• W4313174952 doi "https://doi.org/10.1007/978-981-16-5422-0_213" @default.
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