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- W4313175412 abstract "Depression is a complex, heterogeneous, multifactorial disorder. It can be chronic and recurrent. Another challenge is the emergence of treatment-resistant depression. Identifying and validating novel treatment targets are the need of the hour to overcome these challenges. Even though the monoamine hypothesis is the widely accepted hypothesis to explain the pathophysiology of depression, it will not be enough to explain all the intricacies of the disorder. Experimental animal models are essential tools in studying pathophysiology and finding novel treatments for depression. An ideal animal model should possess face, construct, and predictive validities. It is an uphill task to develop a homologous model using rodents similar to all the depression manifestations experienced by humans. Apart from the classical stress-induced depression models, the researchers are developing and validating novel models involving neuro-inflammation, genetic, epigenetic dysregulation, and models using optogenetic tools." @default.
- W4313175412 created "2023-01-06" @default.
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- W4313175412 date "2022-01-01" @default.
- W4313175412 modified "2023-10-17" @default.
- W4313175412 title "Screening Methods for the Evaluation of Antidepressant Drugs" @default.
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- W4313175412 doi "https://doi.org/10.1007/978-981-19-5343-9_13" @default.
- W4313175412 hasPublicationYear "2022" @default.
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