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- W4313176038 abstract "<b>Background:</b> When estimating long-term mortality of tuberculosis (TB), few studies comprehensively accounted for potential confounders. We aimed to evaluate the risk of long-term mortality in TB survivors and its modifiable risk factors while considering potential confounders. <b>Methods:</b> This population-based cohort study included TB survivors (n=55,739) aged≥20 years between 2010 and 2017, and 1:3 age- and sex-matched controls (n=167,217). The participants were followed up for death one year after study enrolment until December 2018. Long-term mortality was adjusted for smoking, alcohol consumption, exercise, income level, body mass index (BMI), and comorbidities. <b>Results:</b> During a median of 3.8 years of follow-up, the incidence rate of mortality was significantly higher in TB survivors than in matched controls (16.0 vs 7.0/1,000 person-years, p<0.001). Even after adjusting for potential confounders, the mortality risk was 1.64-fold (95% confidence interval, 1.57–1.73) higher in TB survivors than in matched controls. The risk of mortality in TB survivors relative to matched controls significantly increased in participants aged≥40 years with the highest risk in those in their 60s. Lower BMI (adjusted HR[aHR], 1.74) for underweight, current smoking (aHR, 1.40), and low income (aHR, 1.23) were positively associated with increased mortality, while mild alcohol consumption (aHR, 0.80), and regular exercise (aHR, 0.85) reduced the risk of long-term mortality in TB survivors. <b>Conclusion:</b> The long-term mortality risk was significantly higher in TB survivors than in matched controls. There were some preventable risk factors, the modification of which may improve long-term TB-related mortality." @default.
- W4313176038 created "2023-01-06" @default.
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- W4313176038 date "2022-09-04" @default.
- W4313176038 modified "2023-09-23" @default.
- W4313176038 title "Long-term mortality of post-tuberculous survivors in Korea: a population-based longitudinal study" @default.
- W4313176038 doi "https://doi.org/10.1183/13993003.congress-2022.396" @default.
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