FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313176838> ?p ?o ?g. }

• W4313176838 endingPage "123" @default.
• W4313176838 startingPage "99" @default.
• W4313176838 abstract "Human growth hormone is a growth-promoting agent, but also has many additional actions. These include the conservation of protein, the mobilization of free fatty acids from adipose tissue and inhibition of glucose uptake by body tissues. Therefore, somatotropin may be a more appropriate name than growth hormone. Physicochemical characteristics have been studied extensively, and the molecular weight (approximately 21,500), the amino acid content (188 amino acids) and the structural sequence determined. Production rates of growth hormone have not been determined because techniques currently available do not permit such measurements. However, certain normal stimuli, such as exercise and deep sleep, and certain abnormal stimuli, such as insulin-induced hypoglycemia and arginine infusion, cause a significant increase in HGH concentrations in serum. Therefore, growth hormone deficient states can be identified by analyzing serums, which are obtained following the administration of these stimuli, in the radioimmunoassay for growth hormone. Growth hormone deficient states may result from organic lesions in the hypothalamic-pituitary area, secondary to emotional deprivation and for unexplained or idiopathic reasons. The same clinical state is occasionally seen in patients who have measurable growth hormone, but peripheral resistance to this. This type of hypopituitarism and some instances of idiopathic hypopituitarism are genetically determined. Human growth hormone is an effective therapeutic agent in patients with hypopituitarism, in some patients with hypoglycemia and in some intrauterine dwarfs if given in large or pharmacologic amounts. It is ineffective or of limited effectiveness in chondrodystrophies, many types of primordial dwarfism and in gonadal agenesis. Unfortunately, animal growth hormones are ineffective in humans, and monkey growth hormone is impractical to use because of the small yield from monkey pituitaries. Human growth hormone has not been synthesized, and no totally satisfactory substitute has been found. For these reasons, the supply of HGH is limited, and only a few of the many deserving hypopituitary patients have had the benefit of receiving HGH. These and other details of growth hormone action and therapy have been discussed." @default.
• W4313176838 created "2023-01-06" @default.
• W4313176838 creator A5004216125 @default.
• W4313176838 creator A5040955935 @default.
• W4313176838 date "1970-01-01" @default.
• W4313176838 modified "2023-10-01" @default.
• W4313176838 title "Human Growth Hormone:" @default.
• W4313176838 cites W1897220277 @default.
• W4313176838 cites W1965204208 @default.
• W4313176838 cites W1969792648 @default.
• W4313176838 cites W1970191977 @default.
• W4313176838 cites W1972114216 @default.
• W4313176838 cites W1972670989 @default.
• W4313176838 cites W1973758579 @default.
• W4313176838 cites W1978196119 @default.
• W4313176838 cites W1983044920 @default.
• W4313176838 cites W1984505489 @default.
• W4313176838 cites W1987066507 @default.
• W4313176838 cites W1988433684 @default.
• W4313176838 cites W1991416914 @default.
• W4313176838 cites W1994557120 @default.
• W4313176838 cites W1997024138 @default.
• W4313176838 cites W2001536155 @default.
• W4313176838 cites W2001675329 @default.
• W4313176838 cites W2004697262 @default.
• W4313176838 cites W2006541976 @default.
• W4313176838 cites W2007699005 @default.
• W4313176838 cites W2008422198 @default.
• W4313176838 cites W2012898950 @default.
• W4313176838 cites W2019868200 @default.
• W4313176838 cites W2020117297 @default.
• W4313176838 cites W2023301396 @default.
• W4313176838 cites W2026085987 @default.
• W4313176838 cites W2026229202 @default.
• W4313176838 cites W2032803122 @default.
• W4313176838 cites W2033010797 @default.
• W4313176838 cites W2035341819 @default.
• W4313176838 cites W2040318502 @default.
• W4313176838 cites W2041199718 @default.
• W4313176838 cites W2041810645 @default.
• W4313176838 cites W2047102142 @default.
• W4313176838 cites W2048587076 @default.
• W4313176838 cites W2048911874 @default.
• W4313176838 cites W2051409766 @default.
• W4313176838 cites W2058504424 @default.
• W4313176838 cites W2060950552 @default.
• W4313176838 cites W2064584734 @default.
• W4313176838 cites W2067250520 @default.
• W4313176838 cites W2069278398 @default.
• W4313176838 cites W2071132311 @default.
• W4313176838 cites W2074831945 @default.
• W4313176838 cites W2076104915 @default.
• W4313176838 cites W2080710150 @default.
• W4313176838 cites W2082493477 @default.
• W4313176838 cites W2086390579 @default.
• W4313176838 cites W2087867814 @default.
• W4313176838 cites W2089205909 @default.
• W4313176838 cites W2091622340 @default.
• W4313176838 cites W2093699547 @default.
• W4313176838 cites W2096217291 @default.
• W4313176838 cites W2104659473 @default.
• W4313176838 cites W2106290045 @default.
• W4313176838 cites W2106496504 @default.
• W4313176838 cites W2107912786 @default.
• W4313176838 cites W2108367092 @default.
• W4313176838 cites W2111018024 @default.
• W4313176838 cites W2112397102 @default.
• W4313176838 cites W2125168267 @default.
• W4313176838 cites W2125718022 @default.
• W4313176838 cites W2127908566 @default.
• W4313176838 cites W2133175293 @default.
• W4313176838 cites W2145529757 @default.
• W4313176838 cites W2155083715 @default.
• W4313176838 cites W2156435407 @default.
• W4313176838 cites W2157256150 @default.
• W4313176838 cites W2161352373 @default.
• W4313176838 cites W2162499821 @default.
• W4313176838 cites W2182635640 @default.
• W4313176838 cites W2315001756 @default.
• W4313176838 cites W2317591786 @default.
• W4313176838 cites W2318254865 @default.
• W4313176838 cites W2326580668 @default.
• W4313176838 cites W2328553820 @default.
• W4313176838 cites W2337824825 @default.
• W4313176838 cites W2581710718 @default.
• W4313176838 cites W2963052683 @default.
• W4313176838 cites W4249773359 @default.
• W4313176838 cites W4300020900 @default.
• W4313176838 cites W2070460479 @default.
• W4313176838 doi "https://doi.org/10.1016/s0065-3101(22)00532-1" @default.
• W4313176838 hasPublicationYear "1970" @default.
• W4313176838 type Work @default.
• W4313176838 citedByCount "2" @default.
• W4313176838 countsByYear W43131768382018 @default.
• W4313176838 crossrefType "journal-article" @default.
• W4313176838 hasAuthorship W4313176838A5004216125 @default.
• W4313176838 hasAuthorship W4313176838A5040955935 @default.
• W4313176838 hasConcept C104317684 @default.

• next