Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313177400> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4313177400 endingPage "1340" @default.
- W4313177400 startingPage "1335" @default.
- W4313177400 abstract "Sulfamethoxazole (SMX) is the most significant antibiotic in the sulfonamide family. It was chosen as the representative of this category because of its widespread use. Starting with sulfamethoxazole, a new series of 2-Azetidinone (M1-M6) was synthesized, the structure of these new derivatives was confirmed using spectral methods, starting with the synthesis of Schiff’s bases by reflux of different aromatic benzaldehydes, separately, with Sulfamethoxazole in ethanol with few drops of acetic acid. The final compounds were obtained by ketene-imine synthesis of β-lactam using chloroacetyl chloride. The designed chemicals’ synthesis has been completed successfully. Physical parameters (melting points and Rf values), Fourier transform infrared (FT-IR) spectroscopy, and Proton nuclear magnetic resonance (1H-NMR) spectroscopy were used to establish the purity and characterization of these derivatives. When compared to standard antibiotics (Sulfamethoxazole, Ciprofloxacin, and Fluconazole), the preliminary antimicrobial activity tests on four different bacteria strains and one type of fungus demonstrated that the final compounds (M1-M6) have significant activity. Finally, the new derivatives (M3 and M5) are the most potent than the other ones and more active than the standard drugs." @default.
- W4313177400 created "2023-01-06" @default.
- W4313177400 creator A5058626679 @default.
- W4313177400 creator A5082468412 @default.
- W4313177400 date "2022-06-30" @default.
- W4313177400 modified "2023-09-27" @default.
- W4313177400 title "Synthesis, Characterization of New Sulfamethoxazole Derivatives containing β-lactam Ring and Preliminary Evaluation of their Antimicrobial Activity" @default.
- W4313177400 doi "https://doi.org/10.25258/ijddt.12.3.67" @default.
- W4313177400 hasPublicationYear "2022" @default.
- W4313177400 type Work @default.
- W4313177400 citedByCount "0" @default.
- W4313177400 crossrefType "journal-article" @default.
- W4313177400 hasAuthorship W4313177400A5058626679 @default.
- W4313177400 hasAuthorship W4313177400A5082468412 @default.
- W4313177400 hasBestOaLocation W43131774001 @default.
- W4313177400 hasConcept C103319777 @default.
- W4313177400 hasConcept C161790260 @default.
- W4313177400 hasConcept C178790620 @default.
- W4313177400 hasConcept C185592680 @default.
- W4313177400 hasConcept C2776131168 @default.
- W4313177400 hasConcept C2776673659 @default.
- W4313177400 hasConcept C2778695967 @default.
- W4313177400 hasConcept C2779425571 @default.
- W4313177400 hasConcept C2779751237 @default.
- W4313177400 hasConcept C2780978688 @default.
- W4313177400 hasConcept C2781039511 @default.
- W4313177400 hasConcept C4937899 @default.
- W4313177400 hasConcept C501593827 @default.
- W4313177400 hasConcept C55493867 @default.
- W4313177400 hasConceptScore W4313177400C103319777 @default.
- W4313177400 hasConceptScore W4313177400C161790260 @default.
- W4313177400 hasConceptScore W4313177400C178790620 @default.
- W4313177400 hasConceptScore W4313177400C185592680 @default.
- W4313177400 hasConceptScore W4313177400C2776131168 @default.
- W4313177400 hasConceptScore W4313177400C2776673659 @default.
- W4313177400 hasConceptScore W4313177400C2778695967 @default.
- W4313177400 hasConceptScore W4313177400C2779425571 @default.
- W4313177400 hasConceptScore W4313177400C2779751237 @default.
- W4313177400 hasConceptScore W4313177400C2780978688 @default.
- W4313177400 hasConceptScore W4313177400C2781039511 @default.
- W4313177400 hasConceptScore W4313177400C4937899 @default.
- W4313177400 hasConceptScore W4313177400C501593827 @default.
- W4313177400 hasConceptScore W4313177400C55493867 @default.
- W4313177400 hasIssue "03" @default.
- W4313177400 hasLocation W43131774001 @default.
- W4313177400 hasOpenAccess W4313177400 @default.
- W4313177400 hasPrimaryLocation W43131774001 @default.
- W4313177400 hasRelatedWork W2024484112 @default.
- W4313177400 hasRelatedWork W2073284728 @default.
- W4313177400 hasRelatedWork W2126005636 @default.
- W4313177400 hasRelatedWork W2181566700 @default.
- W4313177400 hasRelatedWork W2217848960 @default.
- W4313177400 hasRelatedWork W2731267270 @default.
- W4313177400 hasRelatedWork W2766463389 @default.
- W4313177400 hasRelatedWork W2952988944 @default.
- W4313177400 hasRelatedWork W3201960625 @default.
- W4313177400 hasRelatedWork W4313177400 @default.
- W4313177400 hasVolume "12" @default.
- W4313177400 isParatext "false" @default.
- W4313177400 isRetracted "false" @default.
- W4313177400 workType "article" @default.