Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313178212> ?p ?o ?g. }
- W4313178212 endingPage "1228" @default.
- W4313178212 startingPage "1179" @default.
- W4313178212 abstract "In recent studies, the critical roles of the bone marrow microenvironment (BMME) and mesenchymal stem cells (MSCs) in the pathophysiology of leukemia have been addressed. Yet, the mechanisms need to be defined. Leukemia results from a clonal transformation of hematopoietic precursors by the acquisition of chromosomal rearrangements, genetic mutations, and epigenetic modifications. It has been shown that the initiating intrinsic event then leads to alteration of the BMME to support the survival of leukemic blasts. There is limited data for a primary/initiator role for the BMME leading to the development of leukemia. In humans, the development of myelodysplastic syndrome/secondary acute myeloblastic leukemia years after chemotherapy use, besides intrinsic factors, may point to a critical role of the altered/dysregulated ME in the development of leukemia. Similarly, in inherited diseases with DNA repair defects (e.g., Fanconi anemia), long-term xenobiotic exposure and accumulation in the BMME may contribute to the development of leukemia. These factors suggest a previously underestimated but essential role for the BMME in hematological malignancies. Recently, the role of marrow adipose tissue (MAT), by providing free fatty acids through lipolysis, is being addressed as an important factor supporting leukemic blast survival. On the other hand, adipose tissue inflammation is another topic of interest reported to be associated with obesity, insulin resistance, metabolic syndrome, cardiovascular defects, and cancer. In this chapter, the metabolic response of BMME to stress will be discussed with particular attention to MSCs, MAT, and clinical implications in leukemia." @default.
- W4313178212 created "2023-01-06" @default.
- W4313178212 creator A5032017126 @default.
- W4313178212 creator A5054031394 @default.
- W4313178212 date "2022-01-01" @default.
- W4313178212 modified "2023-09-26" @default.
- W4313178212 title "Response of the Bone Marrow Stem Cells and the Microenvironment to Stress" @default.
- W4313178212 cites W1504660023 @default.
- W4313178212 cites W1577296862 @default.
- W4313178212 cites W1632668007 @default.
- W4313178212 cites W1787222452 @default.
- W4313178212 cites W1850914599 @default.
- W4313178212 cites W1903562890 @default.
- W4313178212 cites W1912410801 @default.
- W4313178212 cites W1920870416 @default.
- W4313178212 cites W1968628080 @default.
- W4313178212 cites W1970036190 @default.
- W4313178212 cites W1974182237 @default.
- W4313178212 cites W1974685102 @default.
- W4313178212 cites W1975058291 @default.
- W4313178212 cites W1975208402 @default.
- W4313178212 cites W1976422788 @default.
- W4313178212 cites W1979295154 @default.
- W4313178212 cites W1980052833 @default.
- W4313178212 cites W1980162425 @default.
- W4313178212 cites W1984693616 @default.
- W4313178212 cites W1985537081 @default.
- W4313178212 cites W1989779923 @default.
- W4313178212 cites W1991069555 @default.
- W4313178212 cites W1991950992 @default.
- W4313178212 cites W1994286339 @default.
- W4313178212 cites W1996481689 @default.
- W4313178212 cites W1997072144 @default.
- W4313178212 cites W1997453928 @default.
- W4313178212 cites W1997508587 @default.
- W4313178212 cites W1998007417 @default.
- W4313178212 cites W1998984090 @default.
- W4313178212 cites W1999112627 @default.
- W4313178212 cites W2000441102 @default.
- W4313178212 cites W2001329246 @default.
- W4313178212 cites W2002889467 @default.
- W4313178212 cites W2005718040 @default.
- W4313178212 cites W2008455196 @default.
- W4313178212 cites W2008825099 @default.
- W4313178212 cites W2009474598 @default.
- W4313178212 cites W2009896818 @default.
- W4313178212 cites W2015886154 @default.
- W4313178212 cites W2024968355 @default.
- W4313178212 cites W2027066896 @default.
- W4313178212 cites W2029085820 @default.
- W4313178212 cites W2030956730 @default.
- W4313178212 cites W2031855875 @default.
- W4313178212 cites W2031870128 @default.
- W4313178212 cites W2031888856 @default.
- W4313178212 cites W2032154992 @default.
- W4313178212 cites W2036838019 @default.
- W4313178212 cites W2037406128 @default.
- W4313178212 cites W2039163665 @default.
- W4313178212 cites W2039748263 @default.
- W4313178212 cites W2041357218 @default.
- W4313178212 cites W2041360667 @default.
- W4313178212 cites W2042914840 @default.
- W4313178212 cites W2044703599 @default.
- W4313178212 cites W2045032252 @default.
- W4313178212 cites W2046960533 @default.
- W4313178212 cites W2050637174 @default.
- W4313178212 cites W2052167378 @default.
- W4313178212 cites W2052396649 @default.
- W4313178212 cites W2052730253 @default.
- W4313178212 cites W2053352622 @default.
- W4313178212 cites W2053712883 @default.
- W4313178212 cites W2056265113 @default.
- W4313178212 cites W2056781574 @default.
- W4313178212 cites W2056839795 @default.
- W4313178212 cites W2057858099 @default.
- W4313178212 cites W2060610551 @default.
- W4313178212 cites W2060930865 @default.
- W4313178212 cites W2064480611 @default.
- W4313178212 cites W2064591701 @default.
- W4313178212 cites W2065226637 @default.
- W4313178212 cites W2069943416 @default.
- W4313178212 cites W2071613225 @default.
- W4313178212 cites W2073585291 @default.
- W4313178212 cites W2077330278 @default.
- W4313178212 cites W2078719918 @default.
- W4313178212 cites W2086243699 @default.
- W4313178212 cites W2086680310 @default.
- W4313178212 cites W2086980881 @default.
- W4313178212 cites W2087990669 @default.
- W4313178212 cites W2088022688 @default.
- W4313178212 cites W2093818708 @default.
- W4313178212 cites W2094391985 @default.
- W4313178212 cites W2096638244 @default.
- W4313178212 cites W2100140007 @default.
- W4313178212 cites W2103735571 @default.
- W4313178212 cites W2108778569 @default.
- W4313178212 cites W2112643617 @default.
- W4313178212 cites W2112703508 @default.