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- W4313179601 abstract "<b>Background:</b> Asthma has been associated with increased comorbidity, but less is known on how asthma severity and glucocorticoid treatment affect comorbidities. <b>Aims and objectives:</b> To analyze the comorbidity burden in relation to asthma severity and corticosteroid burden. <b>Methods:</b> Data were collected from the administrative health care registers covering the whole Finnish population. Adults with a diagnosis of asthma between 2014-2017 were included, and data were collected until 2018. Asthma was defined as never, transiently, and continuously severe based on annual dispensed inhaled (ICS) and oral corticosteroids (OCS) and hospitalizations. <b>Results:</b> A total of 193,730 adult asthma patients were identified of whom 86.3% had never, 8.1% had transiently and 5.6 % had continuously severe asthma. Excess prevalence of pneumonia was observed in continuously (22%) and transiently severe (14%) compared with never severe patients after adjusting for age and gender. Also, cataract, osteoporosis, obesity, heart failure, and atrial fibrillation were more frequent in severe compared to non-severe asthmatics. ICS and OCS use contributed in a dose-dependent manner to the risk of many comorbidities, particularly osteoporosis, pneumonia, and obesity. High OCS use and the presence of comorbidities were associated with increased healthcare resource use. <b>Conclusions:</b> Patients with severe asthma have a high burden of comorbidities and especially pneumonia. Many of the comorbidities have a strong association with ICS and OCS treatment, suggesting that corticosteroid doses should be carefully evaluated in the clinical practice. Supported by GSK." @default.
- W4313179601 created "2023-01-06" @default.
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- W4313179601 date "2022-09-04" @default.
- W4313179601 modified "2023-09-26" @default.
- W4313179601 title "Comorbidities in severe and non-severe asthma: a nationwide population-based observational study" @default.
- W4313179601 doi "https://doi.org/10.1183/13993003.congress-2022.2966" @default.
- W4313179601 hasPublicationYear "2022" @default.
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