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- W4313188039 abstract "Immunotherapy has become an area of keen research interest in the development of novel anticancer treatment following the great success achieved with immune checkpoint inhibitor (ICI) therapy in many types of cancer. Nasopharyngeal carcinoma (NPC) has several unique characteristics that render it potentially suitable for immunotherapy. For patients with locally advanced nasopharyngeal carcinoma (LA-NPC), immunotherapy might not only represent a promising therapeutic strategy to further improve their prognosis but also be adopted to develop de-intensification therapies to reduce treatment-related toxicity and improve patient compliance. The application of ICI therapy, cancer vaccination, and adoptive T cell therapy for patients with LA-NPC is currently being extensively explored. A general introduction to the application of immunotherapy in LA-NPC is provided in this chapter. This chapter begins with an introduction to the common strategies of cancer immunotherapy followed by a discussion about the suitability of immunotherapy for NPC, as well as the mechanism and feasibility of combining immunotherapy with chemotherapy and radiotherapy in LA-NPC. Subsequently, the current application of ICI therapy and other forms of immunotherapy, including cancer vaccination and adoptive T cell therapy in LA-NPC, is also discussed. Particular attention is paid to the most promising ICI therapies." @default.
- W4313188039 created "2023-01-06" @default.
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- W4313188039 date "2022-01-01" @default.
- W4313188039 modified "2023-10-16" @default.
- W4313188039 title "Immunotherapy in Locally Advanced Nasopharyngeal Carcinoma" @default.
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- W4313188039 doi "https://doi.org/10.1007/13905_2022_28" @default.
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