Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313194008> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4313194008 abstract "Background: Antiretroviral therapy (ART) significantly improves the life span of people living with HIV/AIDS (PLWHA). However, HIV- associated cardiovascular diseases (CVDs) remain one of the leading causes of heart failure and comorbidity in PLWHA. Modern ART regimens reduce viral loads to undetectable levels in HIV+ patients while being less toxic. Nevertheless, HIV proteins are present in the plasma of PLWHA. The HIV protein, Nef, has been found circulating in the plasma of ART-treated patients within extracellular vesicles and in association with immune cells. We hypothesized that circulating HIV Nef proteins may cause an adverse effect on various organ functions. To further understand the effect of Nef on differing organ functions, we have generated a transgenic mouse model which expresses the Nef protein in the presence of Cre recombinase. Methods and Results: Nef transgenic mouse model was generated by cloning HIV-1 Nef ORF in CAG-Lox-CAT vector. Transgenic mice lines were crossed with the alpha myosin heavy chain promoter Cre mice to express Nef protein in the heart. Western blot data validated Nef protein expression in the adult mouse heart. Histological evaluation of the effect of Nef protein expression on heart morphology revealed cardiac hypertrophy. Furthermore, heart function analysis shows that Nef expressing mouse lines have depressed heart function. Conclusion: Our study suggests that Nef causes cardiac dysfunction that mimics cardiomyopathy secondary to latent HIV in PLWHA. Further, this mouse model could be useful in studying the effect of Nef protein in different organs or cells using cell-specific Cre recombinase. Moreover, Nef transgenic mice could be useful in generating new therapeutic tools to control comorbidity in PLWHA." @default.
- W4313194008 created "2023-01-06" @default.
- W4313194008 creator A5024314884 @default.
- W4313194008 creator A5033662833 @default.
- W4313194008 creator A5087575001 @default.
- W4313194008 date "2022-08-05" @default.
- W4313194008 modified "2023-10-17" @default.
- W4313194008 title "Abstract P3122: Latent Mouse Model Of HIV-1" @default.
- W4313194008 doi "https://doi.org/10.1161/res.131.suppl_1.p3122" @default.
- W4313194008 hasPublicationYear "2022" @default.
- W4313194008 type Work @default.
- W4313194008 citedByCount "0" @default.
- W4313194008 crossrefType "journal-article" @default.
- W4313194008 hasAuthorship W4313194008A5024314884 @default.
- W4313194008 hasAuthorship W4313194008A5033662833 @default.
- W4313194008 hasAuthorship W4313194008A5087575001 @default.
- W4313194008 hasConcept C102230213 @default.
- W4313194008 hasConcept C104317684 @default.
- W4313194008 hasConcept C125929170 @default.
- W4313194008 hasConcept C126322002 @default.
- W4313194008 hasConcept C141035611 @default.
- W4313194008 hasConcept C159047783 @default.
- W4313194008 hasConcept C203014093 @default.
- W4313194008 hasConcept C2776383484 @default.
- W4313194008 hasConcept C2776415932 @default.
- W4313194008 hasConcept C2778198053 @default.
- W4313194008 hasConcept C2778797674 @default.
- W4313194008 hasConcept C54355233 @default.
- W4313194008 hasConcept C71924100 @default.
- W4313194008 hasConcept C86803240 @default.
- W4313194008 hasConcept C8891405 @default.
- W4313194008 hasConceptScore W4313194008C102230213 @default.
- W4313194008 hasConceptScore W4313194008C104317684 @default.
- W4313194008 hasConceptScore W4313194008C125929170 @default.
- W4313194008 hasConceptScore W4313194008C126322002 @default.
- W4313194008 hasConceptScore W4313194008C141035611 @default.
- W4313194008 hasConceptScore W4313194008C159047783 @default.
- W4313194008 hasConceptScore W4313194008C203014093 @default.
- W4313194008 hasConceptScore W4313194008C2776383484 @default.
- W4313194008 hasConceptScore W4313194008C2776415932 @default.
- W4313194008 hasConceptScore W4313194008C2778198053 @default.
- W4313194008 hasConceptScore W4313194008C2778797674 @default.
- W4313194008 hasConceptScore W4313194008C54355233 @default.
- W4313194008 hasConceptScore W4313194008C71924100 @default.
- W4313194008 hasConceptScore W4313194008C86803240 @default.
- W4313194008 hasConceptScore W4313194008C8891405 @default.
- W4313194008 hasIssue "Suppl_1" @default.
- W4313194008 hasLocation W43131940081 @default.
- W4313194008 hasOpenAccess W4313194008 @default.
- W4313194008 hasPrimaryLocation W43131940081 @default.
- W4313194008 hasRelatedWork W1990488096 @default.
- W4313194008 hasRelatedWork W2024318433 @default.
- W4313194008 hasRelatedWork W2030084515 @default.
- W4313194008 hasRelatedWork W2047783732 @default.
- W4313194008 hasRelatedWork W2055996927 @default.
- W4313194008 hasRelatedWork W2066004117 @default.
- W4313194008 hasRelatedWork W2092803796 @default.
- W4313194008 hasRelatedWork W2156960185 @default.
- W4313194008 hasRelatedWork W2169367958 @default.
- W4313194008 hasRelatedWork W4306964144 @default.
- W4313194008 hasVolume "131" @default.
- W4313194008 isParatext "false" @default.
- W4313194008 isRetracted "false" @default.
- W4313194008 workType "article" @default.