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• W4313196355 endingPage "160" @default.
• W4313196355 startingPage "119" @default.
• W4313196355 abstract "Plants and their bioactive compounds are used in medicinal practices since ancient times. The Himalayan region possesses a large number of medicinal plants, which have been used to prevent and cure several human diseases. Diabetes is a major public health problem, which affects millions of people worldwide. Due to its complexity and impact on whole body hemodynamics, there is no cure for any type of diabetes, and most of the available drugs only help manage the symptoms to a certain extent. Moreover, the development of drug with lesser or no side effects is still a challenge to the medical system. Plant products and their derived active compounds can be possible alternatives for the treatment of diabetes without much adverse effects. Therefore, analysis on such plants and their metabolites has become important. However, routine efforts to identify the plant-based active compounds are not sufficient and there is a need for more rigorous scientific validation to ensure their efficacy, safety, and consistency. In addition, analysis of the chemical structure of a bioactive compound and its relationship with biological activity (structure–activity relationship or SAR) is crucial as it allows the modification of the bioactive compound by changing its chemical structure; this can be considered as a powerful tool in the discovery of drugs, which are very selective and have less side effects. Although several plant-based medicines are being used traditionally for treating diabetes and have been scientifically validated, their mechanism of action is yet to be defined. Here, we review several plant species of the Himalayan region that can be effectively used to treat diabetes and their bioactive compounds having antidiabetic properties and discuss their structure–activity relationship and probable molecular mechanism underlying these properties." @default.
• W4313196355 created "2023-01-06" @default.
• W4313196355 creator A5009089083 @default.
• W4313196355 creator A5046437253 @default.
• W4313196355 creator A5071195046 @default.
• W4313196355 date "2022-01-01" @default.
• W4313196355 modified "2023-10-14" @default.
• W4313196355 title "Himalayan medicinal plants for treatment of diabetes: Their active components and underlying mechanism" @default.
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