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- W4313196425 abstract "Low-frequency Stimulation of the Kindling Focus Delays Basolateral Amygdala Kindling in Immature Rats VelíŠek L, VelíŠkova J, Stanton PK Neurosci Lett 2002;326:61–63. Stimulation of deep brain sites is a new approach for treatment of intractable seizures. In adult rats, low-frequency stimulation (LFS; 1–3 Hz) of the kindling site interferes with the course of kindling epileptogenesis. In this study we determined whether the LFS is effective against the fast kindling in the basolateral amygdala in immature, 15-day-old rats. LFS (15 min of 1-Hz stimulation) was applied after each of the 1-s, 60-Hz kindling stimulus. LFS suppressed afterdischarge duration and seizure stage throughout the course of kindling, which indicates a strong antiepileptogenic potential. As the kindling and LFS stimulation patterns are similar to those used for induction of long-term potentiation and long-term depression (LTD), respectively, LTD or depotentiation may play a role in the mechanism of action." @default.
- W4313196425 created "2023-01-06" @default.
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- W4313196425 date "2002-09-01" @default.
- W4313196425 modified "2023-09-24" @default.
- W4313196425 title "Antiepileptogenesis by Deep Brain Stimulation" @default.
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- W4313196425 doi "https://doi.org/10.1111/j.1535-7597.2002.00057.x" @default.
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