Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313198237> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4313198237 endingPage "179" @default.
- W4313198237 startingPage "2" @default.
- W4313198237 abstract "Ergothioneine (ERGO) is a hydrophilic antioxidant contained in the food and is distributed to the brain after oral intake, exhibiting a neuroprotective effect. ERGO protected PC12 cells against cellular toxicity induced by amyloid beta (Aβ) and improved impairment of learning and memory ability in mice administered with Aβ. However, the effects of ERGO on hyperphosphorylation of tau protein is unclear. In the present study, we investigated whether ERGO suppresses Aβ-induced hyperphosphorylation of tau protein in human neuroblastoma SH-SY5Y cells. SH-SY5Y cells were differentiated using culture medium containing 1% or 10% fetal bovine serum (FBS) with 10 μM retinoic acid. Exposure to Aβ25-35 clearly decreased cellular viability in SH-SY5Y cells differentiated in the 10% FBS medium, but not 1% FBS medium. Pretreatment with ERGO protected SH-SY5Y cells against cellular toxicity induced by Aβ25-35 in a dose-dependent manner. Exposure of SH-SY5Y cells to Aβ25-35 increased expression of phosphorylated tau protein, and the increase was suppressed by pretreatment with ERGO in a dose-dependent manner. These results suggest that ERGO may suppress hyperphosphorylation of tau protein and alleviate neurotoxicity induced by Aβ." @default.
- W4313198237 created "2023-01-06" @default.
- W4313198237 creator A5001812480 @default.
- W4313198237 creator A5005177820 @default.
- W4313198237 creator A5008780348 @default.
- W4313198237 creator A5022762826 @default.
- W4313198237 creator A5026711791 @default.
- W4313198237 creator A5080675618 @default.
- W4313198237 date "2022-01-01" @default.
- W4313198237 modified "2023-10-15" @default.
- W4313198237 title "Suppressive effects of ergothioneine on Aβ-induced hyperphosphorylation of tau protein in SH-SY5Y cells" @default.
- W4313198237 doi "https://doi.org/10.1254/jpssuppl.96.0_2-b-p-179" @default.
- W4313198237 hasPublicationYear "2022" @default.
- W4313198237 type Work @default.
- W4313198237 citedByCount "0" @default.
- W4313198237 crossrefType "journal-article" @default.
- W4313198237 hasAuthorship W4313198237A5001812480 @default.
- W4313198237 hasAuthorship W4313198237A5005177820 @default.
- W4313198237 hasAuthorship W4313198237A5008780348 @default.
- W4313198237 hasAuthorship W4313198237A5022762826 @default.
- W4313198237 hasAuthorship W4313198237A5026711791 @default.
- W4313198237 hasAuthorship W4313198237A5080675618 @default.
- W4313198237 hasBestOaLocation W43131982371 @default.
- W4313198237 hasConcept C11960822 @default.
- W4313198237 hasConcept C126322002 @default.
- W4313198237 hasConcept C1491633281 @default.
- W4313198237 hasConcept C153911025 @default.
- W4313198237 hasConcept C178790620 @default.
- W4313198237 hasConcept C185592680 @default.
- W4313198237 hasConcept C2776715637 @default.
- W4313198237 hasConcept C2778198054 @default.
- W4313198237 hasConcept C2778670691 @default.
- W4313198237 hasConcept C2779083432 @default.
- W4313198237 hasConcept C2779134260 @default.
- W4313198237 hasConcept C2779404806 @default.
- W4313198237 hasConcept C2779491297 @default.
- W4313198237 hasConcept C29730261 @default.
- W4313198237 hasConcept C502032728 @default.
- W4313198237 hasConcept C54355233 @default.
- W4313198237 hasConcept C55493867 @default.
- W4313198237 hasConcept C71924100 @default.
- W4313198237 hasConcept C81885089 @default.
- W4313198237 hasConcept C86803240 @default.
- W4313198237 hasConcept C95444343 @default.
- W4313198237 hasConcept C98274493 @default.
- W4313198237 hasConceptScore W4313198237C11960822 @default.
- W4313198237 hasConceptScore W4313198237C126322002 @default.
- W4313198237 hasConceptScore W4313198237C1491633281 @default.
- W4313198237 hasConceptScore W4313198237C153911025 @default.
- W4313198237 hasConceptScore W4313198237C178790620 @default.
- W4313198237 hasConceptScore W4313198237C185592680 @default.
- W4313198237 hasConceptScore W4313198237C2776715637 @default.
- W4313198237 hasConceptScore W4313198237C2778198054 @default.
- W4313198237 hasConceptScore W4313198237C2778670691 @default.
- W4313198237 hasConceptScore W4313198237C2779083432 @default.
- W4313198237 hasConceptScore W4313198237C2779134260 @default.
- W4313198237 hasConceptScore W4313198237C2779404806 @default.
- W4313198237 hasConceptScore W4313198237C2779491297 @default.
- W4313198237 hasConceptScore W4313198237C29730261 @default.
- W4313198237 hasConceptScore W4313198237C502032728 @default.
- W4313198237 hasConceptScore W4313198237C54355233 @default.
- W4313198237 hasConceptScore W4313198237C55493867 @default.
- W4313198237 hasConceptScore W4313198237C71924100 @default.
- W4313198237 hasConceptScore W4313198237C81885089 @default.
- W4313198237 hasConceptScore W4313198237C86803240 @default.
- W4313198237 hasConceptScore W4313198237C95444343 @default.
- W4313198237 hasConceptScore W4313198237C98274493 @default.
- W4313198237 hasIssue "0" @default.
- W4313198237 hasLocation W43131982371 @default.
- W4313198237 hasOpenAccess W4313198237 @default.
- W4313198237 hasPrimaryLocation W43131982371 @default.
- W4313198237 hasRelatedWork W1985811851 @default.
- W4313198237 hasRelatedWork W2017539720 @default.
- W4313198237 hasRelatedWork W2080497256 @default.
- W4313198237 hasRelatedWork W2081754014 @default.
- W4313198237 hasRelatedWork W2087261778 @default.
- W4313198237 hasRelatedWork W215726525 @default.
- W4313198237 hasRelatedWork W2158693566 @default.
- W4313198237 hasRelatedWork W2395156889 @default.
- W4313198237 hasRelatedWork W3136785936 @default.
- W4313198237 hasRelatedWork W3211542491 @default.
- W4313198237 hasVolume "96" @default.
- W4313198237 isParatext "false" @default.
- W4313198237 isRetracted "false" @default.
- W4313198237 workType "article" @default.