Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313198510> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4313198510 endingPage "A970" @default.
- W4313198510 startingPage "A969.3" @default.
- W4313198510 abstract "Aims, Objectives and Background Reliable risk assessment in patients presenting to emergency departments (ED) with suspected infection is of utmost importance to support clinical decisions. Vital sign-based scoring systems such as NEWS2 or qSOFA enable a rapid first assessment of patient urgency at triage. However, their inherent high sensitivity might drive over-utilization of healthcare resources. Our aim was to evaluate if adding the result of a transcriptomic severity classifier can synergistically improve current score-based risk assessment in the ED. Method and Design We performed a secondary analysis of a patient cohort (n=312) enrolled in the Charité University hospital ED (Berlin, Germany) with suspected infection and at least one vital sign alteration. The expression of 29-host mRNAs in PAXgene-stabilized whole blood was quantified using NanoString nCounter® SPRINT. The proprietary machine learning classifier IMX-SEV-3 was applied to calculate a score that falls into pre-defined interpretation bands: low/moderate/high severity. NEWS2 and qSOFA were documented on admission and combined with the classifier results to analyze the incidence of two clinical endpoints: ‘need for critical care’ (composite of need for ventilation, dialysis, and/or vasopressors) within 7d and ‘28d mortality’. Results and Conclusion Among enrolled patients, 22 (7.1%) died and 66 (21.1%) required ICU-level care. Of patients with a high NEWS2 (≥5 points; n=184), there was a stepwise increase in mortality among the low (0%; n=0/47), medium (10.1%; n=12/119) and high (44.4% n=8/18) IMX-SEV-3 severity subgroups. A similar stratification was achieved across the low (17%), moderate (31%), and high (61%) IMX-SEV-3 subgroups for prediction of critical care. More granular risk stratification could also be confirmed when using IMX-SEV-3 in combination with high qSOFA (≥2 points; n=76): 0/10.6/50% mortality and 23.5/40.4/66% need for critical care in the low/moderate/high subgroups, respectively. In summary, the combined use of immune-based IMX-SEV-3 results for ED patients with high clinical scores allows improved prediction of mortality and the need for critical care." @default.
- W4313198510 created "2023-01-06" @default.
- W4313198510 creator A5009410215 @default.
- W4313198510 creator A5029933928 @default.
- W4313198510 creator A5051195358 @default.
- W4313198510 creator A5054071252 @default.
- W4313198510 creator A5058341211 @default.
- W4313198510 creator A5059850426 @default.
- W4313198510 date "2022-11-22" @default.
- W4313198510 modified "2023-10-02" @default.
- W4313198510 title "1726 Integrating established clinical scores with a novel transcriptomic severity classifier augments early risk assessment in the ED" @default.
- W4313198510 doi "https://doi.org/10.1136/emermed-2022-rcem2.14" @default.
- W4313198510 hasPublicationYear "2022" @default.
- W4313198510 type Work @default.
- W4313198510 citedByCount "0" @default.
- W4313198510 crossrefType "journal-article" @default.
- W4313198510 hasAuthorship W4313198510A5009410215 @default.
- W4313198510 hasAuthorship W4313198510A5029933928 @default.
- W4313198510 hasAuthorship W4313198510A5051195358 @default.
- W4313198510 hasAuthorship W4313198510A5054071252 @default.
- W4313198510 hasAuthorship W4313198510A5058341211 @default.
- W4313198510 hasAuthorship W4313198510A5059850426 @default.
- W4313198510 hasBestOaLocation W43131985101 @default.
- W4313198510 hasConcept C118552586 @default.
- W4313198510 hasConcept C119857082 @default.
- W4313198510 hasConcept C126322002 @default.
- W4313198510 hasConcept C194828623 @default.
- W4313198510 hasConcept C2776376669 @default.
- W4313198510 hasConcept C2777120189 @default.
- W4313198510 hasConcept C2777671062 @default.
- W4313198510 hasConcept C2780347030 @default.
- W4313198510 hasConcept C2780724011 @default.
- W4313198510 hasConcept C30036603 @default.
- W4313198510 hasConcept C41008148 @default.
- W4313198510 hasConcept C71924100 @default.
- W4313198510 hasConceptScore W4313198510C118552586 @default.
- W4313198510 hasConceptScore W4313198510C119857082 @default.
- W4313198510 hasConceptScore W4313198510C126322002 @default.
- W4313198510 hasConceptScore W4313198510C194828623 @default.
- W4313198510 hasConceptScore W4313198510C2776376669 @default.
- W4313198510 hasConceptScore W4313198510C2777120189 @default.
- W4313198510 hasConceptScore W4313198510C2777671062 @default.
- W4313198510 hasConceptScore W4313198510C2780347030 @default.
- W4313198510 hasConceptScore W4313198510C2780724011 @default.
- W4313198510 hasConceptScore W4313198510C30036603 @default.
- W4313198510 hasConceptScore W4313198510C41008148 @default.
- W4313198510 hasConceptScore W4313198510C71924100 @default.
- W4313198510 hasIssue "12" @default.
- W4313198510 hasLocation W43131985101 @default.
- W4313198510 hasOpenAccess W4313198510 @default.
- W4313198510 hasPrimaryLocation W43131985101 @default.
- W4313198510 hasRelatedWork W1982716358 @default.
- W4313198510 hasRelatedWork W2116710500 @default.
- W4313198510 hasRelatedWork W2116933628 @default.
- W4313198510 hasRelatedWork W2469363752 @default.
- W4313198510 hasRelatedWork W2598298581 @default.
- W4313198510 hasRelatedWork W2912136334 @default.
- W4313198510 hasRelatedWork W2980180104 @default.
- W4313198510 hasRelatedWork W3025628854 @default.
- W4313198510 hasRelatedWork W3120294537 @default.
- W4313198510 hasRelatedWork W3183690287 @default.
- W4313198510 hasVolume "39" @default.
- W4313198510 isParatext "false" @default.
- W4313198510 isRetracted "false" @default.
- W4313198510 workType "article" @default.