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- W4313198629 abstract "Uricosuric agents, such as benzbromarone and probenecid, are of limited use due to the risk of their drug-induced liver injury (DILI) and drug-drug interactions (DDIs). We have developed a novel uricosuric agent, dotinurad, that has a potent pharmacological effect while avoiding these risks. Inhibitory effect of dotinurad on mitochondrial function, an index of hepatotoxicity, was weak and there was no observation suggesting a risk of DILI taking into consideration the clinical dose or exposure. According to the guideline, dotinurad was assessed not to have a risk of DDI caused by inhibition of CYPs or transporters." @default.
- W4313198629 created "2023-01-06" @default.
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- W4313198629 date "2022-01-01" @default.
- W4313198629 modified "2023-09-25" @default.
- W4313198629 title "Discovery and profile of dotinurad, a selective urate reabsorption inhibitor" @default.
- W4313198629 doi "https://doi.org/10.1254/jpssuppl.96.0_4-b-w14-3" @default.
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