Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313198805> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4313198805 endingPage "176" @default.
- W4313198805 startingPage "2" @default.
- W4313198805 abstract "Curcumin has been reported to exert its anti-SARS-CoV-2 activity through multiple mechanisms including inhibition of spike receptor-binding domain (RBD) to angiotensin-converting enzyme-2 (ACE2) binding. To identify more potent compounds, we tested curcumin and its analogs for spike RBD-ACE2 binding inhibitory activity and antiviral activity in SARS-CoV-2-infected cells. An artificial intelligence (AI) -supported activity prediction system was used to select the compounds, and 116 compounds with a docking score range of -8.7 to -4.3 kcal/mol were selected from 334 curcumin analogs. These compounds were narrowed down to 10 compounds, including curcumin, for confirmatory studies. These 10 compounds showed a significant correlation (rs=0.685, P=0.029) between the IC20 values of spike-RBD-ACE2 binding inhibitory activity and EC50 values of antiviral activity, indicating that the antiviral activity was mediated by spike RBD-ACE2 binding inhibition. Based on the assumption that the binding site of curcumin and its analogs is different from that of anti-spike RBD antibody drugs, it is expected that these compounds through pharmaceutical or pharmacokinetic modification, or the development of more potent derivatives would contribute to supplementing the antiviral activity of antibodies against SARS-CoV-2." @default.
- W4313198805 created "2023-01-06" @default.
- W4313198805 creator A5017838982 @default.
- W4313198805 creator A5020898779 @default.
- W4313198805 creator A5035438468 @default.
- W4313198805 creator A5039156689 @default.
- W4313198805 creator A5039695127 @default.
- W4313198805 creator A5050403450 @default.
- W4313198805 creator A5055095348 @default.
- W4313198805 creator A5072325590 @default.
- W4313198805 creator A5091230710 @default.
- W4313198805 date "2022-01-01" @default.
- W4313198805 modified "2023-10-17" @default.
- W4313198805 title "Antiviral activity of curcumin and its analogs selected by artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells" @default.
- W4313198805 doi "https://doi.org/10.1254/jpssuppl.96.0_2-b-p-176" @default.
- W4313198805 hasPublicationYear "2022" @default.
- W4313198805 type Work @default.
- W4313198805 citedByCount "0" @default.
- W4313198805 crossrefType "journal-article" @default.
- W4313198805 hasAuthorship W4313198805A5017838982 @default.
- W4313198805 hasAuthorship W4313198805A5020898779 @default.
- W4313198805 hasAuthorship W4313198805A5035438468 @default.
- W4313198805 hasAuthorship W4313198805A5039156689 @default.
- W4313198805 hasAuthorship W4313198805A5039695127 @default.
- W4313198805 hasAuthorship W4313198805A5050403450 @default.
- W4313198805 hasAuthorship W4313198805A5055095348 @default.
- W4313198805 hasAuthorship W4313198805A5072325590 @default.
- W4313198805 hasAuthorship W4313198805A5091230710 @default.
- W4313198805 hasBestOaLocation W43131988051 @default.
- W4313198805 hasConcept C142724271 @default.
- W4313198805 hasConcept C159110408 @default.
- W4313198805 hasConcept C181199279 @default.
- W4313198805 hasConcept C185592680 @default.
- W4313198805 hasConcept C202751555 @default.
- W4313198805 hasConcept C2777648638 @default.
- W4313198805 hasConcept C2778250585 @default.
- W4313198805 hasConcept C2779134260 @default.
- W4313198805 hasConcept C3007834351 @default.
- W4313198805 hasConcept C3008058167 @default.
- W4313198805 hasConcept C41685203 @default.
- W4313198805 hasConcept C524204448 @default.
- W4313198805 hasConcept C55493867 @default.
- W4313198805 hasConcept C71240020 @default.
- W4313198805 hasConcept C71924100 @default.
- W4313198805 hasConcept C86803240 @default.
- W4313198805 hasConcept C96529984 @default.
- W4313198805 hasConcept C98274493 @default.
- W4313198805 hasConceptScore W4313198805C142724271 @default.
- W4313198805 hasConceptScore W4313198805C159110408 @default.
- W4313198805 hasConceptScore W4313198805C181199279 @default.
- W4313198805 hasConceptScore W4313198805C185592680 @default.
- W4313198805 hasConceptScore W4313198805C202751555 @default.
- W4313198805 hasConceptScore W4313198805C2777648638 @default.
- W4313198805 hasConceptScore W4313198805C2778250585 @default.
- W4313198805 hasConceptScore W4313198805C2779134260 @default.
- W4313198805 hasConceptScore W4313198805C3007834351 @default.
- W4313198805 hasConceptScore W4313198805C3008058167 @default.
- W4313198805 hasConceptScore W4313198805C41685203 @default.
- W4313198805 hasConceptScore W4313198805C524204448 @default.
- W4313198805 hasConceptScore W4313198805C55493867 @default.
- W4313198805 hasConceptScore W4313198805C71240020 @default.
- W4313198805 hasConceptScore W4313198805C71924100 @default.
- W4313198805 hasConceptScore W4313198805C86803240 @default.
- W4313198805 hasConceptScore W4313198805C96529984 @default.
- W4313198805 hasConceptScore W4313198805C98274493 @default.
- W4313198805 hasIssue "0" @default.
- W4313198805 hasLocation W43131988051 @default.
- W4313198805 hasLocation W43131988052 @default.
- W4313198805 hasOpenAccess W4313198805 @default.
- W4313198805 hasPrimaryLocation W43131988051 @default.
- W4313198805 hasRelatedWork W3013048436 @default.
- W4313198805 hasRelatedWork W3023213585 @default.
- W4313198805 hasRelatedWork W3084498529 @default.
- W4313198805 hasRelatedWork W3087427886 @default.
- W4313198805 hasRelatedWork W3087747856 @default.
- W4313198805 hasRelatedWork W3119779361 @default.
- W4313198805 hasRelatedWork W3134376730 @default.
- W4313198805 hasRelatedWork W3152387439 @default.
- W4313198805 hasRelatedWork W3156800464 @default.
- W4313198805 hasRelatedWork W3195836061 @default.
- W4313198805 hasVolume "96" @default.
- W4313198805 isParatext "false" @default.
- W4313198805 isRetracted "false" @default.
- W4313198805 workType "article" @default.